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The tremor of chronic alcoholism, although clinically similar to essential tremor, has been considered a distinct syndrome. Its underlying mechanism was analyzed in five patients (none in the acute stages of alcohol withdrawal) hospitalized in an alcohol detoxification program. All five patients performed tracking tasks in which they pursued a linearly moving "target" light with a response light that they controlled by flexion-extension activity of the wrist. Stationary and dynamic targets were used with both isometric and unconstrained wrist mechanical interfaces. Frequency, torque, and displacement tremor characteristics were examined under varying inertial loading or isometric voluntary torque conditions. Two simultaneous tremor components were present in all patients: a prominent 4- to 7-Hz low-frequency peak and a smaller-amplitude 9.4- to 9.6-Hz high-frequency peak. As the inertia of the hand was augmented during unconstrained tasks, the low-frequency peak decreased, while the high-frequency peak was unaffected. As required voluntary effort was increased during isometric testing, the amplitude of the low-frequency peak increased. These findings suggest that the low-frequency peak represents the significant pathologic component of the tremor of chronic alcoholism and that it has a biomechanical reflex mechanism similar to that of the lower-amplitude normal physiologic tremor.
M L Aisen, and
B D Adelstein, and
J Romero, and
A Morris, and
M Rosen
November 1985,
Neurology,
M L Aisen, and
B D Adelstein, and
J Romero, and
A Morris, and
M Rosen
December 1950,
The Journal of laboratory and clinical medicine,
M L Aisen, and
B D Adelstein, and
J Romero, and
A Morris, and
M Rosen
August 1987,
Klinicheskaia meditsina,
M L Aisen, and
B D Adelstein, and
J Romero, and
A Morris, and
M Rosen
October 1972,
Journal des sciences medicales de Lille,
M L Aisen, and
B D Adelstein, and
J Romero, and
A Morris, and
M Rosen
November 1977,
Polskie Archiwum Medycyny Wewnetrznej,
M L Aisen, and
B D Adelstein, and
J Romero, and
A Morris, and
M Rosen
April 1986,
Klinicheskaia meditsina,
M L Aisen, and
B D Adelstein, and
J Romero, and
A Morris, and
M Rosen
January 2008,
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference,
M L Aisen, and
B D Adelstein, and
J Romero, and
A Morris, and
M Rosen
January 1986,
Alcohol and alcoholism (Oxford, Oxfordshire),
M L Aisen, and
B D Adelstein, and
J Romero, and
A Morris, and
M Rosen
August 1983,
Neurology,
M L Aisen, and
B D Adelstein, and
J Romero, and
A Morris, and
M Rosen
February 1999,
Biological cybernetics,
