-transparent.png){kind=logo}
Xanthohumol metabolites in faeces of rats. 2004
Aslieh Nookandeh, and
Norbert Frank, and
Frank Steiner, and
Renate Ellinger, and
Bernd Schneider, and
Clarissa Gerhäuser, and
Hans Becker
Institute for Pharmacognosy and Analytical Phytochemistry, University of the Saarland, 66041 Saarbrücken, Germany.
Xanthohumol (1), isolated from hop, was fed to rats in a dose of 1000 mg kg(-1) body weight. The faeces of the animals were collected after 24 and 48 h and analysed for metabolites of 1. Approximately 89% of the recovered flavonoid-compounds consisted of unchanged 1. Sixteen metabolites and six previously known metabolites were isolated and characterized by coupling techniques (HPLC-NMR, HPLC-MS and HPLC-DAD). Their structures were elucidated by spectroscopic methods, especially using NMR spectroscopy. Twenty metabolites had a modified chalcone structure and two metabolites were flavanone derivatives.
Related Publications
Aslieh Nookandeh, and
Norbert Frank, and
Frank Steiner, and
Renate Ellinger, and
Bernd Schneider, and
Clarissa Gerhäuser, and
Hans Becker
March 2012,
Molecular nutrition & food research,
Aslieh Nookandeh, and
Norbert Frank, and
Frank Steiner, and
Renate Ellinger, and
Bernd Schneider, and
Clarissa Gerhäuser, and
Hans Becker
October 2001,
Laboratory animals,
Aslieh Nookandeh, and
Norbert Frank, and
Frank Steiner, and
Renate Ellinger, and
Bernd Schneider, and
Clarissa Gerhäuser, and
Hans Becker
May 1968,
Chemistry & industry,
Aslieh Nookandeh, and
Norbert Frank, and
Frank Steiner, and
Renate Ellinger, and
Bernd Schneider, and
Clarissa Gerhäuser, and
Hans Becker
January 1991,
Drug metabolism and drug interactions,
Aslieh Nookandeh, and
Norbert Frank, and
Frank Steiner, and
Renate Ellinger, and
Bernd Schneider, and
Clarissa Gerhäuser, and
Hans Becker
January 1973,
Acta pharmacologica et toxicologica,
Aslieh Nookandeh, and
Norbert Frank, and
Frank Steiner, and
Renate Ellinger, and
Bernd Schneider, and
Clarissa Gerhäuser, and
Hans Becker
November 2003,
Chemical & pharmaceutical bulletin,
Aslieh Nookandeh, and
Norbert Frank, and
Frank Steiner, and
Renate Ellinger, and
Bernd Schneider, and
Clarissa Gerhäuser, and
Hans Becker
February 2002,
Veterinary research communications,
Aslieh Nookandeh, and
Norbert Frank, and
Frank Steiner, and
Renate Ellinger, and
Bernd Schneider, and
Clarissa Gerhäuser, and
Hans Becker
October 1970,
European journal of biochemistry,
Aslieh Nookandeh, and
Norbert Frank, and
Frank Steiner, and
Renate Ellinger, and
Bernd Schneider, and
Clarissa Gerhäuser, and
Hans Becker
August 1977,
The Journal of pharmacy and pharmacology,
Aslieh Nookandeh, and
Norbert Frank, and
Frank Steiner, and
Renate Ellinger, and
Bernd Schneider, and
Clarissa Gerhäuser, and
Hans Becker
June 1977,
West African journal of pharmacology and drug research,
