BIOMAT Database Logo BIOMAT Database Logo

Transbilayer movement of phospholipids in biogenic membranes. 2004

Matthijs A Kol, and Anton I P M de Kroon, and J Antoinette Killian, and Ben de Kruijff
Department of Biochemistry of Membranes, Centre for Biomembranes and Lipid Enzymology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

Biogenic membranes contain the enzymes that synthesize the cell's membrane lipids, of which the phospholipids are the most widespread throughout nature. Being synthesized at and inserted into the cytoplasmic leaflet of biogenic membranes, the phospholipids must migrate to the opposite leaflet to ensure balanced growth of the membrane. In this review, the current knowledge of transbilayer movement of phospholipids in biogenic membranes is summarized and the available data are compared to what is known about lipid translocation in other membranes. On the basis of this, a mechanism is proposed, in which phospholipid translocation in biogenic membranes is mediated via membrane-spanning segments of a subset of proteins, characterized by a small number of transmembrane helices. We speculate that proteins of this subset facilitate lipid translocation via the protein-lipid interface, because they display more dynamic behavior and engage in less stable protein-lipid interactions than larger membrane proteins.

UI MeSH Term Description Entries
D008051 Lipid Bilayers Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes. Bilayers, Lipid,Bilayer, Lipid,Lipid Bilayer
D010743 Phospholipids Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system. Phosphatides,Phospholipid
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001692 Biological Transport The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments. Transport, Biological,Biologic Transport,Transport, Biologic
D021962 Membrane Microdomains Detergent-insoluble CELL MEMBRANE components. They are enriched in SPHINGOLIPIDS and CHOLESTEROL and clustered with glycosyl-phosphatidylinositol (GPI)-anchored proteins. Lipid Rafts, Cell Membrane,Sphingolipid Microdomains,Sphingolipid-Cholesterol Rafts,Membrane Microdomain,Microdomain, Membrane,Microdomain, Sphingolipid,Microdomains, Membrane,Microdomains, Sphingolipid,Sphingolipid Cholesterol Rafts,Sphingolipid Microdomain,Sphingolipid-Cholesterol Raft

Related Publications

Matthijs A Kol, and Anton I P M de Kroon, and J Antoinette Killian, and Ben de Kruijff
Transbilayer movement of phospholipids in red cell and platelet membranes.
November 1991, Biochimica et biophysica acta,
Matthijs A Kol, and Anton I P M de Kroon, and J Antoinette Killian, and Ben de Kruijff
Transbilayer distribution of phospholipids in bacteriophage membranes.
October 2007, Biochimica et biophysica acta,
Matthijs A Kol, and Anton I P M de Kroon, and J Antoinette Killian, and Ben de Kruijff
Transbilayer complementarity of phospholipids in cholesterol-rich membranes.
March 2005, Biochemistry,
Matthijs A Kol, and Anton I P M de Kroon, and J Antoinette Killian, and Ben de Kruijff
Transbilayer movement of bile acids in model membranes.
April 1987, Biochemistry,
Matthijs A Kol, and Anton I P M de Kroon, and J Antoinette Killian, and Ben de Kruijff
Transbilayer movement of fluorescent phospholipids in Bacillus megaterium membrane vesicles.
April 1997, Biochemistry,
Matthijs A Kol, and Anton I P M de Kroon, and J Antoinette Killian, and Ben de Kruijff
Transbilayer movement of phospholipids at the main phase transition of lipid membranes: implications for rapid flip-flop in biological membranes.
December 2002, Biophysical journal,
Matthijs A Kol, and Anton I P M de Kroon, and J Antoinette Killian, and Ben de Kruijff
Transbilayer distribution and movement of lysophosphatidylcholine in liposomal membranes.
March 1977, Biochimica et biophysica acta,
Matthijs A Kol, and Anton I P M de Kroon, and J Antoinette Killian, and Ben de Kruijff
Ceramide-induced transbilayer (flip-flop) lipid movement in membranes.
January 2009, Methods in molecular biology (Clifton, N.J.),
Matthijs A Kol, and Anton I P M de Kroon, and J Antoinette Killian, and Ben de Kruijff
Abnormal transbilayer distribution of phospholipids in red blood cell membranes in schizophrenia.
September 2009, Psychiatry research,
Matthijs A Kol, and Anton I P M de Kroon, and J Antoinette Killian, and Ben de Kruijff
Transbilayer movement of monohexosylsphingolipids in endoplasmic reticulum and Golgi membranes.
October 2002, Biochemistry,
Copied contents to your clipboard!