BIOMAT Database Logo BIOMAT Database Logo

Polyamine excretion in depleted patients with gastrointestinal malignancy: effect of perioperative nutrition and tumor removal. 1992

M J Pöyhönen, and J A Takala, and O Pitkänen, and A Kari, and E Alhava, and L A Alakuijala, and T O Eloranta
Department of Anesthesiology, Kuopio University Hospital, Finland.

Polyamines, synthesized by all mammalian cells, are involved in protein and energy metabolism. We measured urinary excretion of polyamines, putrescine, spermidine, spermine, and their metabolites N1-acetylspermidine and N8-acetylspermidine, resting energy expenditure, and nitrogen excretion in 12 depleted patients with gastrointestinal malignancy during preoperative and postoperative parenteral nutrition and in 7 patients with multiple trauma receiving similar parenteral nutrition. During preoperative nutrition support, the excretion of putrescine (p less than .05) and total polyamines (p less than .01) increased by 420% and 60%, respectively. Increases in energy balance and resting energy expenditure during nutrition could entirely explain the observed changes in polyamine excretion. Preoperatively, the excretion of N1-acetylspermidine (p less than .05), N8-acetylspermidine (p less than .001) and total polyamines (p less than .05) was higher in patients with a surgically noncurable tumor than in those with a surgically curable tumor. The energy balance and resting energy expenditure could also explain the differences in polyamine excretion between patients with surgically curable and noncurable disease, excluding the increased N8-acetylspermidine. Postoperatively, the excretion of N8-acetylspermidine in patients with multiple trauma without malignancy and in patients with palliative operation was similar, and was higher than in patients with a totally resected malignancy (p less than .01). Our results suggest that the excretion of polyamines reflects the activity of energy metabolism in general and that polyamine excretion is not specific for any particular disease.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009104 Multiple Trauma Multiple physical insults or injuries occurring simultaneously. Injuries, Multiple,Trauma, Multiple,Wounds, Multiple,Multiple Injuries,Polytrauma,Injury, Multiple,Multiple Injury,Multiple Traumas,Multiple Wound,Multiple Wounds,Polytraumas,Traumas, Multiple,Wound, Multiple
D009584 Nitrogen An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.
D010289 Parenteral Nutrition, Total The delivery of nutrients for assimilation and utilization by a patient whose sole source of nutrients is via solutions administered intravenously, subcutaneously, or by some other non-alimentary route. The basic components of TPN solutions are protein hydrolysates or free amino acid mixtures, monosaccharides, and electrolytes. Components are selected for their ability to reverse catabolism, promote anabolism, and build structural proteins. Hyperalimentation, Parenteral,Intravenous Hyperalimentation,Nutrition, Total Parenteral,Parenteral Hyperalimentation,Total Parenteral Nutrition,Hyperalimentation, Intravenous
D011073 Polyamines Amine compounds that consist of carbon chains or rings containing two or more primary amino groups. Polyamine
D004734 Energy Metabolism The chemical reactions involved in the production and utilization of various forms of energy in cells. Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D005260 Female Females
D005770 Gastrointestinal Neoplasms Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL. Gastrointestinal Cancer,Cancer of Gastrointestinal Tract,Cancer of the Gastrointestinal Tract,Neoplasms, Gastrointestinal,Cancer, Gastrointestinal,Cancers, Gastrointestinal,Gastrointestinal Cancers,Gastrointestinal Neoplasm,Gastrointestinal Tract Cancer,Gastrointestinal Tract Cancers,Neoplasm, Gastrointestinal
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

M J Pöyhönen, and J A Takala, and O Pitkänen, and A Kari, and E Alhava, and L A Alakuijala, and T O Eloranta
Urinary polyamine levels in patients with gastrointestinal malignancy.
December 1975, Cancer,
M J Pöyhönen, and J A Takala, and O Pitkänen, and A Kari, and E Alhava, and L A Alakuijala, and T O Eloranta
Perioperative nutrition of patients with gastrointestinal cancer.
October 2002, The British journal of surgery,
M J Pöyhönen, and J A Takala, and O Pitkänen, and A Kari, and E Alhava, and L A Alakuijala, and T O Eloranta
Perioperative total parenteral nutrition in patients with gastrointestinal cancer.
May 1981, The Journal of surgical research,
M J Pöyhönen, and J A Takala, and O Pitkänen, and A Kari, and E Alhava, and L A Alakuijala, and T O Eloranta
[Polyamine excretion in patients with tumors].
January 1976, Voprosy onkologii,
M J Pöyhönen, and J A Takala, and O Pitkänen, and A Kari, and E Alhava, and L A Alakuijala, and T O Eloranta
Perioperative artificial nutrition in malnourished gastrointestinal cancer patients.
April 2006, World journal of gastroenterology,
M J Pöyhönen, and J A Takala, and O Pitkänen, and A Kari, and E Alhava, and L A Alakuijala, and T O Eloranta
Polyamine metabolism and polyamine excretion in normal and tumor bearing rodents.
January 1985, Anticancer research,
M J Pöyhönen, and J A Takala, and O Pitkänen, and A Kari, and E Alhava, and L A Alakuijala, and T O Eloranta
Effect of Perioperative Dexmedetomidine Anesthesia on Prognosis of Elderly Patients with Gastrointestinal Tumor Surgery.
January 2022, Computational and mathematical methods in medicine,
M J Pöyhönen, and J A Takala, and O Pitkänen, and A Kari, and E Alhava, and L A Alakuijala, and T O Eloranta
Urinary polyamine levels in patients with localized malignancy.
September 1976, Cancer,
M J Pöyhönen, and J A Takala, and O Pitkänen, and A Kari, and E Alhava, and L A Alakuijala, and T O Eloranta
Excretion of acetylated and free polyamines by polyamine depleted Chinese hamster ovary cells.
January 1989, The International journal of biochemistry,
M J Pöyhönen, and J A Takala, and O Pitkänen, and A Kari, and E Alhava, and L A Alakuijala, and T O Eloranta
[Perioperative nutrition for gastrointestinal surgery].
February 2004, Nihon Geka Gakkai zasshi,
Copied contents to your clipboard!