BIOMAT Database Logo BIOMAT Database Logo

Involvement of forebrain imidazoline and alpha(2)-adrenergic receptors in the antidipsogenic response to moxonidine. 2003

Carina A F Andrade, and Lisandra B Oliveira, and Gizele Martinez, and Daniela C F Silva, and Laurival A De Luca, and Jose V Menani
Department of Physiology and Pathology, School of Dentistry, Paulista State University, 14.801-903 Araraquara, SP, Brazil.

We investigated the participation of central alpha(2)-adrenoceptors and imidazoline receptors in the inhibition of water deprivation-induced water intake in rats. The alpha(2)-adrenoceptor and imidazoline antagonist idazoxan (320 nmol), but not the alpha(2)-adrenoceptor antagonist yohimbine, abolished the antidipsogenic effect of moxonidine (alpha(2)-adrenoceptor and imidazoline agonist, 20 nmol) microinjected into the medial septal area. Yohimbine abolished the antidipsogenic effect of moxonidine intracerebroventricularly. Therefore, central moxonidine may inhibit water intake acting independently on both imidazoline receptors and alpha(2)-adrenoceptors at different forebrain sites.

UI MeSH Term Description Entries
D007093 Imidazoles Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
D007276 Injections, Intraventricular Injections into the cerebral ventricles. Intraventricular Injections,Injection, Intraventricular,Intraventricular Injection
D008297 Male Males
D011955 Receptors, Drug Proteins that bind specific drugs with high affinity and trigger intracellular changes influencing the behavior of cells. Drug receptors are generally thought to be receptors for some endogenous substance not otherwise specified. Drug Receptors,Drug Receptor,Receptor, Drug
D004326 Drinking The consumption of liquids. Water Consumption,Water Intake,Drinkings
D000317 Adrenergic alpha-Antagonists Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. Adrenergic alpha-Receptor Blockaders,alpha-Adrenergic Blocking Agents,alpha-Adrenergic Receptor Blockaders,alpha-Blockers, Adrenergic,Adrenergic alpha-Blockers,alpha-Adrenergic Antagonists,alpha-Adrenergic Blockers,Adrenergic alpha Antagonists,Adrenergic alpha Blockers,Adrenergic alpha Receptor Blockaders,Agents, alpha-Adrenergic Blocking,Antagonists, alpha-Adrenergic,Blockaders, Adrenergic alpha-Receptor,Blockaders, alpha-Adrenergic Receptor,Blockers, alpha-Adrenergic,Blocking Agents, alpha-Adrenergic,Receptor Blockaders, alpha-Adrenergic,alpha Adrenergic Antagonists,alpha Adrenergic Blockers,alpha Adrenergic Blocking Agents,alpha Adrenergic Receptor Blockaders,alpha Blockers, Adrenergic,alpha-Antagonists, Adrenergic,alpha-Receptor Blockaders, Adrenergic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000959 Antihypertensive Agents Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. Anti-Hypertensive,Anti-Hypertensive Agent,Anti-Hypertensive Drug,Antihypertensive,Antihypertensive Agent,Antihypertensive Drug,Anti-Hypertensive Agents,Anti-Hypertensive Drugs,Anti-Hypertensives,Antihypertensive Drugs,Antihypertensives,Agent, Anti-Hypertensive,Agent, Antihypertensive,Agents, Anti-Hypertensive,Agents, Antihypertensive,Anti Hypertensive,Anti Hypertensive Agent,Anti Hypertensive Agents,Anti Hypertensive Drug,Anti Hypertensive Drugs,Anti Hypertensives,Drug, Anti-Hypertensive,Drug, Antihypertensive,Drugs, Anti-Hypertensive,Drugs, Antihypertensive
D014868 Water Deprivation The withholding of water in a structured experimental situation. Deprivation, Water,Deprivations, Water,Water Deprivations
D015016 Yohimbine A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION. Rauwolscine,Aphrodine Hydrochloride,Aphrodyne,Corynanthine,Corynanthine Tartrate,Pluriviron,Rauhimbine,Yocon,Yohimbin Spiegel,Yohimbine Houdé,Yohimbine Hydrochloride,Yohimex,Hydrochloride, Aphrodine,Hydrochloride, Yohimbine,Tartrate, Corynanthine

Related Publications

Carina A F Andrade, and Lisandra B Oliveira, and Gizele Martinez, and Daniela C F Silva, and Laurival A De Luca, and Jose V Menani
[Selectivity of alpha 2-adrenergic agonists for the imidazoline-guanidine and alpha 2-adrenergic receptors].
July 1989, Archives des maladies du coeur et des vaisseaux,
Carina A F Andrade, and Lisandra B Oliveira, and Gizele Martinez, and Daniela C F Silva, and Laurival A De Luca, and Jose V Menani
Different affinities of alpha 2-agonists for imidazoline and alpha 2-adrenergic receptors.
June 1989, American journal of hypertension,
Carina A F Andrade, and Lisandra B Oliveira, and Gizele Martinez, and Daniela C F Silva, and Laurival A De Luca, and Jose V Menani
Moxonidine, a mixed alpha(2)-adrenergic and imidazoline receptor agonist, identifies a novel adrenergic target for spinal analgesia.
December 2003, Annals of the New York Academy of Sciences,
Carina A F Andrade, and Lisandra B Oliveira, and Gizele Martinez, and Daniela C F Silva, and Laurival A De Luca, and Jose V Menani
Presynaptic imidazoline receptors and alpha 2-adrenoceptors in the human heart: discrimination by clonidine and moxonidine.
November 1996, Naunyn-Schmiedeberg's archives of pharmacology,
Carina A F Andrade, and Lisandra B Oliveira, and Gizele Martinez, and Daniela C F Silva, and Laurival A De Luca, and Jose V Menani
Psychopharmacology of imidazoline and alpha 2-adrenergic receptors: implications for depression.
January 1994, Critical reviews in neurobiology,
Carina A F Andrade, and Lisandra B Oliveira, and Gizele Martinez, and Daniela C F Silva, and Laurival A De Luca, and Jose V Menani
Relationship between alpha 2-adrenergic receptors and imidazoline/guanidinium receptive sites.
January 1998, Advances in pharmacology (San Diego, Calif.),
Carina A F Andrade, and Lisandra B Oliveira, and Gizele Martinez, and Daniela C F Silva, and Laurival A De Luca, and Jose V Menani
Conformationally defined adrenergic agents. 2. Catechol imidazoline derivatives: biological effects at alpha 1 and alpha 2 adrenergic receptors.
April 1986, Journal of medicinal chemistry,
Carina A F Andrade, and Lisandra B Oliveira, and Gizele Martinez, and Daniela C F Silva, and Laurival A De Luca, and Jose V Menani
Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors.
December 2003, Annals of the New York Academy of Sciences,
Carina A F Andrade, and Lisandra B Oliveira, and Gizele Martinez, and Daniela C F Silva, and Laurival A De Luca, and Jose V Menani
Involvement of presynaptic imidazoline receptors in the alpha 2-adrenoceptor-independent inhibition of noradrenaline release by imidazoline derivatives.
March 1991, Naunyn-Schmiedeberg's archives of pharmacology,
Carina A F Andrade, and Lisandra B Oliveira, and Gizele Martinez, and Daniela C F Silva, and Laurival A De Luca, and Jose V Menani
Effects of the I(1) imidazoline/alpha(2)-adrenergic receptor agonist moxonidine in comparison with clonidine in the formalin test in rats.
March 2000, Pain,
Copied contents to your clipboard!