Left ventricular thrombosis is associated with increased mean platelet volume in patients with dilated cardiomyopathy and sinus rhythm. 2004

Mehmet Birhan Yilmaz, and Yesim Akin, and Senay Funda Biyikoglu, and Umit Guray, and Halil L Kisacik, and Sule Korkmaz
Yuksek Ihtisas Hospital, Cardiology Clinic, Sihhiye, Ankara, Turkey. cardioceptor@ttnet.net.tr

OBJECTIVE Dilated cardiomyopathy has been associated with left ventricular thrombosis, which leads to substantial morbidity and mortality as a site for peripheral emboli. There are some studies on patients with dilated cardiomyopathy showing altered haemostasis and platelet behaviour despite sinus rhythm. Mean platelet volume, which is the most accurate and simple estimate of platelet reactivity, may be associated with the development of left ventricular thrombosis. RESULTS We prospectively enrolled 48 consecutive patients with dilated cardiomyopathy and sinus rhythm with left ventricular thrombosis and compared them with an age-sex-matched control group having dilated cardiomyopathy without left ventricular thrombosis. We found that in patients with left ventricular thrombosis mean platelet volume is significantly higher than those without (9.5 +/- 0.8 vs. 8.7 +/- 0.6, p < 0.001). CONCLUSIONS Mean platelet volume is increased in patients with dilated cardiomyopathy and sinus rhythm having left ventricular thrombosis. This might be reflecting a causal relationship, which in turn requires further study to establish the role of antiplatelet agents both in prevention and in treatment.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010976 Platelet Count The number of PLATELETS per unit volume in a sample of venous BLOOD. Blood Platelet Count,Blood Platelet Number,Platelet Number,Blood Platelet Counts,Blood Platelet Numbers,Count, Blood Platelet,Count, Platelet,Counts, Blood Platelet,Counts, Platelet,Number, Blood Platelet,Number, Platelet,Numbers, Blood Platelet,Numbers, Platelet,Platelet Count, Blood,Platelet Counts,Platelet Counts, Blood,Platelet Number, Blood,Platelet Numbers,Platelet Numbers, Blood
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D001792 Blood Platelets Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation. Platelets,Thrombocytes,Blood Platelet,Platelet,Platelet, Blood,Platelets, Blood,Thrombocyte
D002311 Cardiomyopathy, Dilated A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein. Cardiomyopathy, Congestive,Congestive Cardiomyopathy,Dilated Cardiomyopathy,Cardiomyopathy, Dilated, 1a,Cardiomyopathy, Dilated, Autosomal Recessive,Cardiomyopathy, Dilated, CMD1A,Cardiomyopathy, Dilated, LMNA,Cardiomyopathy, Dilated, With Conduction Defect 1,Cardiomyopathy, Dilated, with Conduction Deffect1,Cardiomyopathy, Familial Idiopathic,Cardiomyopathy, Idiopathic Dilated,Cardiomyopathies, Congestive,Cardiomyopathies, Dilated,Cardiomyopathies, Familial Idiopathic,Cardiomyopathies, Idiopathic Dilated,Congestive Cardiomyopathies,Dilated Cardiomyopathies,Dilated Cardiomyopathies, Idiopathic,Dilated Cardiomyopathy, Idiopathic,Familial Idiopathic Cardiomyopathies,Familial Idiopathic Cardiomyopathy,Idiopathic Cardiomyopathies, Familial,Idiopathic Cardiomyopathy, Familial,Idiopathic Dilated Cardiomyopathies,Idiopathic Dilated Cardiomyopathy
D004562 Electrocardiography Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY. 12-Lead ECG,12-Lead EKG,12-Lead Electrocardiography,Cardiography,ECG,EKG,Electrocardiogram,Electrocardiograph,12 Lead ECG,12 Lead EKG,12 Lead Electrocardiography,12-Lead ECGs,12-Lead EKGs,12-Lead Electrocardiographies,Cardiographies,ECG, 12-Lead,EKG, 12-Lead,Electrocardiograms,Electrocardiographies, 12-Lead,Electrocardiographs,Electrocardiography, 12-Lead
D005260 Female Females
D006331 Heart Diseases Pathological conditions involving the HEART including its structural and functional abnormalities. Cardiac Disorders,Heart Disorders,Cardiac Diseases,Cardiac Disease,Cardiac Disorder,Heart Disease,Heart Disorder
D006352 Heart Ventricles The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation. Cardiac Ventricle,Cardiac Ventricles,Heart Ventricle,Left Ventricle,Right Ventricle,Left Ventricles,Right Ventricles,Ventricle, Cardiac,Ventricle, Heart,Ventricle, Left,Ventricle, Right,Ventricles, Cardiac,Ventricles, Heart,Ventricles, Left,Ventricles, Right

Related Publications

Mehmet Birhan Yilmaz, and Yesim Akin, and Senay Funda Biyikoglu, and Umit Guray, and Halil L Kisacik, and Sule Korkmaz
October 2012, Angiology,
Mehmet Birhan Yilmaz, and Yesim Akin, and Senay Funda Biyikoglu, and Umit Guray, and Halil L Kisacik, and Sule Korkmaz
January 2012, Medical archives (Sarajevo, Bosnia and Herzegovina),
Mehmet Birhan Yilmaz, and Yesim Akin, and Senay Funda Biyikoglu, and Umit Guray, and Halil L Kisacik, and Sule Korkmaz
January 2009, Scandinavian journal of clinical and laboratory investigation,
Mehmet Birhan Yilmaz, and Yesim Akin, and Senay Funda Biyikoglu, and Umit Guray, and Halil L Kisacik, and Sule Korkmaz
October 2012, Angiology,
Mehmet Birhan Yilmaz, and Yesim Akin, and Senay Funda Biyikoglu, and Umit Guray, and Halil L Kisacik, and Sule Korkmaz
July 2012, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis,
Mehmet Birhan Yilmaz, and Yesim Akin, and Senay Funda Biyikoglu, and Umit Guray, and Halil L Kisacik, and Sule Korkmaz
July 2016, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
Mehmet Birhan Yilmaz, and Yesim Akin, and Senay Funda Biyikoglu, and Umit Guray, and Halil L Kisacik, and Sule Korkmaz
January 2012, Platelets,
Mehmet Birhan Yilmaz, and Yesim Akin, and Senay Funda Biyikoglu, and Umit Guray, and Halil L Kisacik, and Sule Korkmaz
August 2015, Cardiology in the young,
Mehmet Birhan Yilmaz, and Yesim Akin, and Senay Funda Biyikoglu, and Umit Guray, and Halil L Kisacik, and Sule Korkmaz
November 2010, The Tohoku journal of experimental medicine,
Mehmet Birhan Yilmaz, and Yesim Akin, and Senay Funda Biyikoglu, and Umit Guray, and Halil L Kisacik, and Sule Korkmaz
January 2013, Platelets,
Copied contents to your clipboard!