7-Nitroindazole blocks conditioned place preference but not hyperactivity induced by morphine. 2004

Carmen Manzanedo, and María A Aguilar, and Marta Rodríguez-Arias, and Miguel Navarro, and José Miñarro
Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, 28223 Madrid, Spain.

The effects of 7-nitroindazole (7-NI), a neural nitric oxide synthase (nNOS) inhibitor, on spontaneous locomotor activity, morphine-induced hyperactivity, acquisition of place conditioning and morphine-induced conditioned place preference (CPP) were evaluated in male mice. In experiment 1, animals treated with 7-NI (25, 50 and 100mg/kg), morphine (40 mg/kg) or morphine (40 mg/kg) plus 7-NI (25, 50 or 100mg/kg) were placed in an actimeter for 3h. In experiment 2, animals treated with the same drugs and doses were conditioned following an unbiased procedure. 7-NI did not affect the spontaneous locomotor activity or hyperactivity induced by morphine. However, the moderate and high doses of 7-NI produced conditioned place aversion (CPA) and the lowest dose blocked morphine-induced CPP. Our results suggest that nitric oxide is involved in the rewarding properties of morphine but not in its motor effects.

UI MeSH Term Description Entries
D007191 Indazoles A group of heterocyclic aromatic organic compounds consisting of the fusion of BENZENE and PYRAZOLES. Indazole
D008297 Male Males
D009020 Morphine The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. Morphine Sulfate,Duramorph,MS Contin,Morphia,Morphine Chloride,Morphine Sulfate (2:1), Anhydrous,Morphine Sulfate (2:1), Pentahydrate,Oramorph SR,SDZ 202-250,SDZ202-250,Chloride, Morphine,Contin, MS,SDZ 202 250,SDZ 202250,SDZ202 250,SDZ202250,Sulfate, Morphine
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D003216 Conditioning, Operant Learning situations in which the sequence responses of the subject are instrumental in producing reinforcement. When the correct response occurs, which involves the selection from among a repertoire of responses, the subject is immediately reinforced. Instrumental Learning,Learning, Instrumental,Operant Conditioning,Conditionings, Operant,Instrumental Learnings,Learnings, Instrumental,Operant Conditionings
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004791 Enzyme Inhibitors Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. Enzyme Inhibitor,Inhibitor, Enzyme,Inhibitors, Enzyme
D006948 Hyperkinesis Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders. Hyperactivity, Motor,Hyperkinesia,Hyperkinesia, Generalized,Hyperkinetic Movements,Generalized Hyperkinesia,Generalized Hyperkinesias,Hyperkinesias, Generalized,Hyperkinetic Movement,Motor Hyperactivity,Movement, Hyperkinetic,Movements, Hyperkinetic
D000701 Analgesics, Opioid Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. Opioid,Opioid Analgesic,Opioid Analgesics,Opioids,Full Opioid Agonists,Opioid Full Agonists,Opioid Mixed Agonist-Antagonists,Opioid Partial Agonists,Partial Opioid Agonists,Agonist-Antagonists, Opioid Mixed,Agonists, Full Opioid,Agonists, Opioid Full,Agonists, Opioid Partial,Agonists, Partial Opioid,Analgesic, Opioid,Full Agonists, Opioid,Mixed Agonist-Antagonists, Opioid,Opioid Agonists, Full,Opioid Agonists, Partial,Opioid Mixed Agonist Antagonists,Partial Agonists, Opioid
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Carmen Manzanedo, and María A Aguilar, and Marta Rodríguez-Arias, and Miguel Navarro, and José Miñarro
April 2000, Neuroreport,
Carmen Manzanedo, and María A Aguilar, and Marta Rodríguez-Arias, and Miguel Navarro, and José Miñarro
March 2010, Brain research,
Carmen Manzanedo, and María A Aguilar, and Marta Rodríguez-Arias, and Miguel Navarro, and José Miñarro
April 2009, Pharmacology, biochemistry, and behavior,
Carmen Manzanedo, and María A Aguilar, and Marta Rodríguez-Arias, and Miguel Navarro, and José Miñarro
January 2022, Frontiers in neuroscience,
Carmen Manzanedo, and María A Aguilar, and Marta Rodríguez-Arias, and Miguel Navarro, and José Miñarro
December 2004, Pharmacology, biochemistry, and behavior,
Carmen Manzanedo, and María A Aguilar, and Marta Rodríguez-Arias, and Miguel Navarro, and José Miñarro
March 2000, Brain research,
Carmen Manzanedo, and María A Aguilar, and Marta Rodríguez-Arias, and Miguel Navarro, and José Miñarro
December 2018, Neuropharmacology,
Carmen Manzanedo, and María A Aguilar, and Marta Rodríguez-Arias, and Miguel Navarro, and José Miñarro
May 2002, European journal of pharmacology,
Carmen Manzanedo, and María A Aguilar, and Marta Rodríguez-Arias, and Miguel Navarro, and José Miñarro
January 2020, Frontiers in behavioral neuroscience,
Carmen Manzanedo, and María A Aguilar, and Marta Rodríguez-Arias, and Miguel Navarro, and José Miñarro
February 2022, Behavioural brain research,
Copied contents to your clipboard!