-transparent.png){kind=logo}
Synthesis and evaluation of gastroprotective and antiulcer activity of some 2-substituted-1H-imidazo[4,5-b] pyridines and -1H-benzimidazoles. 1992
M Loriga, and
G Paglietti, and
S Piras, and
F Sparatore, and
V Anania, and
M P Demontis, and
M V Varoni, and
M C Fattaccio
Istituto di Chimica Farmaceutica e Tossicologica, Università di Sassari.
Several compounds possessing imidazo[4,5-b]pyridine and benzimidazole structure bearing substituents in position 2 were prepared in order to evaluate an anti-ulcer and gastroprotective activity in rat pylorus ligature, in comparison with omeprazole. Among sixteen compounds taken as representatives of the synthetised series only one (3d) showed a good activity by i.m. administration at 50 mg/kg, while by oral administration of 100 mg/kg a certain number was active and in some cases this activity was quite superior to that of omeprazole.
Related Publications
M Loriga, and
G Paglietti, and
S Piras, and
F Sparatore, and
V Anania, and
M P Demontis, and
M V Varoni, and
M C Fattaccio
December 1998,
Anti-cancer drug design,
M Loriga, and
G Paglietti, and
S Piras, and
F Sparatore, and
V Anania, and
M P Demontis, and
M V Varoni, and
M C Fattaccio
May 2020,
Bioorganic chemistry,
M Loriga, and
G Paglietti, and
S Piras, and
F Sparatore, and
V Anania, and
M P Demontis, and
M V Varoni, and
M C Fattaccio
December 2022,
Molecules (Basel, Switzerland),
M Loriga, and
G Paglietti, and
S Piras, and
F Sparatore, and
V Anania, and
M P Demontis, and
M V Varoni, and
M C Fattaccio
May 2013,
Organic & biomolecular chemistry,
M Loriga, and
G Paglietti, and
S Piras, and
F Sparatore, and
V Anania, and
M P Demontis, and
M V Varoni, and
M C Fattaccio
June 2003,
Bioorganic & medicinal chemistry,
M Loriga, and
G Paglietti, and
S Piras, and
F Sparatore, and
V Anania, and
M P Demontis, and
M V Varoni, and
M C Fattaccio
October 1987,
Journal of medicinal chemistry,
M Loriga, and
G Paglietti, and
S Piras, and
F Sparatore, and
V Anania, and
M P Demontis, and
M V Varoni, and
M C Fattaccio
October 2014,
ACS combinatorial science,
M Loriga, and
G Paglietti, and
S Piras, and
F Sparatore, and
V Anania, and
M P Demontis, and
M V Varoni, and
M C Fattaccio
September 1978,
Journal of medicinal chemistry,
M Loriga, and
G Paglietti, and
S Piras, and
F Sparatore, and
V Anania, and
M P Demontis, and
M V Varoni, and
M C Fattaccio
September 1989,
Journal of medicinal chemistry,
M Loriga, and
G Paglietti, and
S Piras, and
F Sparatore, and
V Anania, and
M P Demontis, and
M V Varoni, and
M C Fattaccio
December 1981,
Il Farmaco; edizione scientifica,
