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A simple, rapid, sensitive and accurate indirect spectrophotometric method for the microdetermination of isoniazid (INH) in pure form and pharmaceutical formulations is developed. The procedure is based on the reaction of copper(II) with isoniazid in the presence of neocuproine (NC). In the presence of neocuproine, copper(II) is reduced easily by isoniazid to a Cu(I)-neocuproine complex, which shows an absorption maximum at 454 nm. By measuring the absorbance of the complex at this wavelength, isoniazid can be determined in the range 0.3-3.5 microgml-1. This method was applied to the determination of isoniazid in pharmaceutical formulation and enabled the determination of the isoniazid in microgram quantities (0.3-3.5 microgml-1). The results obtained for the assay of pharmaceutical preparations compared well with those obtained by the official method and demonstrated good accuracy and precision.
A Safavi, and
M A Karimi, and
M R Hormozi Nezhad, and
R Kamali, and
N Saghir
October 1970,
Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology,
A Safavi, and
M A Karimi, and
M R Hormozi Nezhad, and
R Kamali, and
N Saghir
October 1970,
Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology,
A Safavi, and
M A Karimi, and
M R Hormozi Nezhad, and
R Kamali, and
N Saghir
June 2004,
Talanta,
A Safavi, and
M A Karimi, and
M R Hormozi Nezhad, and
R Kamali, and
N Saghir
January 1984,
Talanta,
A Safavi, and
M A Karimi, and
M R Hormozi Nezhad, and
R Kamali, and
N Saghir
October 1985,
Talanta,
A Safavi, and
M A Karimi, and
M R Hormozi Nezhad, and
R Kamali, and
N Saghir
June 1971,
Clinical chemistry,
A Safavi, and
M A Karimi, and
M R Hormozi Nezhad, and
R Kamali, and
N Saghir
February 1972,
Biochemical medicine,
A Safavi, and
M A Karimi, and
M R Hormozi Nezhad, and
R Kamali, and
N Saghir
June 2007,
International journal of biomedical science : IJBS,
A Safavi, and
M A Karimi, and
M R Hormozi Nezhad, and
R Kamali, and
N Saghir
June 1973,
Journal of pharmaceutical sciences,
A Safavi, and
M A Karimi, and
M R Hormozi Nezhad, and
R Kamali, and
N Saghir
October 1964,
The Journal of pharmacy and pharmacology,
