The spatial orientation of Helicobacter pylori in the gastric mucus. 2004

Sören Schreiber, and Manuela Konradt, and Claudia Groll, and Peter Scheid, and Guido Hanauer, and Hans-Otto Werling, and Christine Josenhans, and Sebastian Suerbaum
Institut für Physiologie, Ruhr-Universität Bochum, D-44780 Bochum, Germany. soeren.shreiber@ruhr-uni-bochum.de

The highly motile human pathogen Helicobacter pylori lives deep in the gastric mucus layer. To identify which chemical gradient guides the bacteria within the mucus layer, combinations of luminal perfusion, dialysis, and ventilation were used to modify or invert transmucus gradients in anaesthetized Helicobacter-infected mice and Mongolian gerbils. Neither changes in lumen or arterial pH nor inversion of bicarbonate/CO2 or urea/ammonium gradients disturbed Helicobacter orientation. However, elimination of the mucus pH gradient by simultaneous reduction of arterial pH and bicarbonate concentration perturbed orientation, causing the bacteria to spread over the entire mucus layer. H. pylori thus uses the gastric mucus pH gradient for chemotactic orientation.

UI MeSH Term Description Entries
D002245 Carbon Dioxide A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D005260 Female Females
D005753 Gastric Mucosa Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones. Cardiac Glands,Gastric Glands,Pyloric Glands,Cardiac Gland,Gastric Gland,Gastric Mucosas,Gland, Cardiac,Gland, Gastric,Gland, Pyloric,Glands, Cardiac,Glands, Gastric,Glands, Pyloric,Mucosa, Gastric,Mucosas, Gastric,Pyloric Gland
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D000644 Quaternary Ammonium Compounds Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN Quaternary Ammonium Compound,Ammonium Compound, Quaternary,Ammonium Compounds, Quaternary,Compound, Quaternary Ammonium
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001639 Bicarbonates Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity. Bicarbonate,Bicarbonate Ions,Hydrogen Carbonates,Bicarbonate Ion,Carbonic Acid Ions,Hydrogen Carbonate,Carbonate, Hydrogen,Carbonates, Hydrogen,Ion, Bicarbonate,Ions, Bicarbonate,Ions, Carbonic Acid
D014508 Urea A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. Basodexan,Carbamide,Carmol
D016480 Helicobacter pylori A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405). Campylobacter pylori,Campylobacter pylori subsp. pylori,Campylobacter pyloridis,Helicobacter nemestrinae
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

Sören Schreiber, and Manuela Konradt, and Claudia Groll, and Peter Scheid, and Guido Hanauer, and Hans-Otto Werling, and Christine Josenhans, and Sebastian Suerbaum
March 1990, Lancet (London, England),
Sören Schreiber, and Manuela Konradt, and Claudia Groll, and Peter Scheid, and Guido Hanauer, and Hans-Otto Werling, and Christine Josenhans, and Sebastian Suerbaum
October 1995, Gut,
Sören Schreiber, and Manuela Konradt, and Claudia Groll, and Peter Scheid, and Guido Hanauer, and Hans-Otto Werling, and Christine Josenhans, and Sebastian Suerbaum
February 2002, Nihon rinsho. Japanese journal of clinical medicine,
Sören Schreiber, and Manuela Konradt, and Claudia Groll, and Peter Scheid, and Guido Hanauer, and Hans-Otto Werling, and Christine Josenhans, and Sebastian Suerbaum
August 1995, Gut,
Sören Schreiber, and Manuela Konradt, and Claudia Groll, and Peter Scheid, and Guido Hanauer, and Hans-Otto Werling, and Christine Josenhans, and Sebastian Suerbaum
January 1991, Journal of clinical pathology,
Sören Schreiber, and Manuela Konradt, and Claudia Groll, and Peter Scheid, and Guido Hanauer, and Hans-Otto Werling, and Christine Josenhans, and Sebastian Suerbaum
January 1990, Lancet (London, England),
Sören Schreiber, and Manuela Konradt, and Claudia Groll, and Peter Scheid, and Guido Hanauer, and Hans-Otto Werling, and Christine Josenhans, and Sebastian Suerbaum
May 1998, Journal of gastroenterology and hepatology,
Sören Schreiber, and Manuela Konradt, and Claudia Groll, and Peter Scheid, and Guido Hanauer, and Hans-Otto Werling, and Christine Josenhans, and Sebastian Suerbaum
January 2000, Microbes and infection,
Sören Schreiber, and Manuela Konradt, and Claudia Groll, and Peter Scheid, and Guido Hanauer, and Hans-Otto Werling, and Christine Josenhans, and Sebastian Suerbaum
May 1997, Biochemical Society transactions,
Sören Schreiber, and Manuela Konradt, and Claudia Groll, and Peter Scheid, and Guido Hanauer, and Hans-Otto Werling, and Christine Josenhans, and Sebastian Suerbaum
March 1995, Gut,
Copied contents to your clipboard!