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Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission. 2004
Cynthia A Derdeyn, and
Julie M Decker, and
Frederic Bibollet-Ruche, and
John L Mokili, and
Mark Muldoon, and
Scott A Denham, and
Marintha L Heil, and
Francis Kasolo, and
Rosemary Musonda, and
Beatrice H Hahn, and
George M Shaw, and
Bette T Korber, and
Susan Allen, and
Eric Hunter
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
Heterosexual transmission accounts for the majority of human immunodeficiency virus-1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.
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