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In vitro responses of human peripheral blood lymphocytes (PBL) were found to be markedly enhanced by culture at 40 degrees C rather than at the conventional temperature of 37 degrees C. We studied proliferative responses of lymphocytes by activation by phytohemagglutinin (PHA) concanavalin A (Con A), pokeweed mitogen (PWM), and allogeneic lymphocytes in mixed lymphocyte culture (MLC) and found enhancement of DNA synthesis at the higher temperature. Cytotoxic T cell responses to allogeneic cells were also enhanced when MLC was done at 40 degrees C. These enhanced immune responses appear to be due in part to increased numbers of participating cells. If in vitro lymphocyte responses correlate with in vivo responses, then fever associated with infection or tumor may be beneficial whereas that associated with autoimmune disorders may have a detrimental effect.
J B Smith, and
R P Knowlton, and
S S Agarwal
January 1994,
Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University,
J B Smith, and
R P Knowlton, and
S S Agarwal
January 1986,
Bioelectromagnetics,
J B Smith, and
R P Knowlton, and
S S Agarwal
February 1968,
Journal of reproduction and fertility,
J B Smith, and
R P Knowlton, and
S S Agarwal
March 1924,
The Journal of general physiology,
J B Smith, and
R P Knowlton, and
S S Agarwal
March 1998,
Mayo Clinic proceedings,
J B Smith, and
R P Knowlton, and
S S Agarwal
January 1988,
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,
J B Smith, and
R P Knowlton, and
S S Agarwal
August 1954,
Electroencephalography and clinical neurophysiology,
J B Smith, and
R P Knowlton, and
S S Agarwal
June 1965,
Experientia,
J B Smith, and
R P Knowlton, and
S S Agarwal
February 1984,
Infusionstherapie und klinische Ernahrung,
J B Smith, and
R P Knowlton, and
S S Agarwal
April 1994,
Transplantation proceedings,
