BIOMAT Database Logo BIOMAT Database Logo

Mammalian artificial chromosomes. 1992

W R Brown
Biochemistry Department, Oxford University, UK.

A mammalian artificial chromosome would enable analysis of the cis-acting DNA sequences necessary for mammalian chromosome function and would allow large numbers of genes in a defined sequence environment to be introduced into experimental animals, agricultural livestock or human cells. Recent technical progress suggests that a route to mammalian artificial chromosome construction is now open.

UI MeSH Term Description Entries
D008322 Mammals Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young. Mammalia,Mammal
D002503 Centromere The clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division. Centromeres
D002875 Chromosomes In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) Chromosome
D005813 Genes, Synthetic Biologically functional sequences of DNA chemically synthesized in vitro. Artificial Genes,Synthetic Genes,Artificial Gene,Gene, Artificial,Gene, Synthetic,Genes, Artificial,Synthetic Gene
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015825 Chromosomes, Fungal Structures within the nucleus of fungal cells consisting of or containing DNA, which carry genetic information essential to the cell. Chromosome, Fungal,Fungal Chromosome,Fungal Chromosomes
D016615 Telomere A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. Its length is believed to be a few hundred base pairs. Telomeres

Related Publications

W R Brown
Mammalian artificial chromosomes
October 2000, Nature biotechnology,
W R Brown
Therapeutic mammalian artificial episomal chromosomes.
April 1999, Current opinion in molecular therapeutics,
W R Brown
Mammalian artificial chromosomes: A review.
January 1996, Cytotechnology,
W R Brown
Mammalian artificial chromosomes and chromosome transgenics.
September 1997, Trends in genetics : TIG,
W R Brown
Making CENs of mammalian artificial chromosomes.
October 1999, Molecular genetics and metabolism,
W R Brown
Construction of YAC-based mammalian artificial chromosomes.
May 1998, Nature biotechnology,
W R Brown
Mammalian artificial chromosomes as tools for gene therapy.
June 1998, Current opinion in genetics & development,
W R Brown
Mammalian artificial chromosomes--vectors for somatic gene therapy.
October 1997, Cancer letters,
W R Brown
Mammalian artificial chromosomes as vectors: progress and prospects.
January 2001, Cloning and stem cells,
W R Brown
Interspecific transfer of mammalian artificial chromosomes between farm animals.
January 2009, Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology,
Copied contents to your clipboard!