The genomic sequence and comparative analysis of the rat major histocompatibility complex. 2004

Peter Hurt, and Lutz Walter, and Ralf Sudbrak, and Sven Klages, and Ines Müller, and Takashi Shiina, and Hidetoshi Inoko, and Hans Lehrach, and Eberhard Günther, and Richard Reinhardt, and Heinz Himmelbauer
Max-Planck-Institut für molekulare Genetik, D-14195 Berlin-Dahlem, Germany.

We have determined the sequence of a 4-Mb interval on rat chromosome 20p12 that encompasses the rat major histocompatibility complex (MHC). This is the first report of a finished sequence for a segment of the rat genome and constitutes one of the largest contiguous sequences thus far for rodent genomes in general. The rat MHC is, next to the human MHC, the second mammalian MHC sequenced to completion. Our analysis has resulted in the identification of at least 220 genes located within the sequenced interval. Although gene content and order are well conserved in the class II and class III gene intervals as well as the framework gene regions, profound rat-specific features were encountered within the class I gene regions, in comparison to human and mouse. Class I region-associated differences were found both at the structural level, the number, and organization of class I genes and gene families, and, in a more global context, in the way that evolution worked to shape the present-day rat MHC.

UI MeSH Term Description Entries
D008285 Major Histocompatibility Complex The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement. Histocompatibility Complex,Complex, Histocompatibility,Complex, Major Histocompatibility,Complices, Histocompatibility,Complices, Major Histocompatibility,Histocompatibility Complex, Major,Histocompatibility Complices,Histocompatibility Complices, Major,Major Histocompatibility Complices
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D010802 Phylogeny The relationships of groups of organisms as reflected by their genetic makeup. Community Phylogenetics,Molecular Phylogenetics,Phylogenetic Analyses,Phylogenetic Analysis,Phylogenetic Clustering,Phylogenetic Comparative Analysis,Phylogenetic Comparative Methods,Phylogenetic Distance,Phylogenetic Generalized Least Squares,Phylogenetic Groups,Phylogenetic Incongruence,Phylogenetic Inference,Phylogenetic Networks,Phylogenetic Reconstruction,Phylogenetic Relatedness,Phylogenetic Relationships,Phylogenetic Signal,Phylogenetic Structure,Phylogenetic Tree,Phylogenetic Trees,Phylogenomics,Analyse, Phylogenetic,Analysis, Phylogenetic,Analysis, Phylogenetic Comparative,Clustering, Phylogenetic,Community Phylogenetic,Comparative Analysis, Phylogenetic,Comparative Method, Phylogenetic,Distance, Phylogenetic,Group, Phylogenetic,Incongruence, Phylogenetic,Inference, Phylogenetic,Method, Phylogenetic Comparative,Molecular Phylogenetic,Network, Phylogenetic,Phylogenetic Analyse,Phylogenetic Clusterings,Phylogenetic Comparative Analyses,Phylogenetic Comparative Method,Phylogenetic Distances,Phylogenetic Group,Phylogenetic Incongruences,Phylogenetic Inferences,Phylogenetic Network,Phylogenetic Reconstructions,Phylogenetic Relatednesses,Phylogenetic Relationship,Phylogenetic Signals,Phylogenetic Structures,Phylogenetic, Community,Phylogenetic, Molecular,Phylogenies,Phylogenomic,Reconstruction, Phylogenetic,Relatedness, Phylogenetic,Relationship, Phylogenetic,Signal, Phylogenetic,Structure, Phylogenetic,Tree, Phylogenetic
D011110 Polymorphism, Genetic The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D011914 Rats, Inbred BN An inbred strain of rat that is widely used in a variety of research areas such as the study of ASTHMA; CARCINOGENESIS; AGING; and LEUKEMIA. Rats, Inbred Brown Norway,Rats, BN,BN Rat,BN Rat, Inbred,BN Rats,BN Rats, Inbred,Inbred BN Rat,Inbred BN Rats,Rat, BN,Rat, Inbred BN
D011917 Rats, Inbred Lew An inbred strain of rat that is used in BIOMEDICAL RESEARCH. Rats, Inbred Lewis,Rats, Lew,Inbred Lew Rat,Inbred Lew Rats,Inbred Lewis Rats,Lew Rat,Lew Rat, Inbred,Lew Rats,Lew Rats, Inbred,Lewis Rats, Inbred,Rat, Inbred Lew,Rat, Lew
D005796 Genes A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. Cistron,Gene,Genetic Materials,Cistrons,Genetic Material,Material, Genetic,Materials, Genetic
D005805 Genes, MHC Class I Genetic loci in the vertebrate major histocompatibility complex which encode polymorphic characteristics not related to immune responsiveness or complement activity, e.g., B loci (chicken), DLA (dog), GPLA (guinea pig), H-2 (mouse), RT-1 (rat), HLA-A, -B, and -C class I genes of man. Class I Genes,Genes, Class I,Genes, H-2 Class I,Genes, HLA Class I,MHC Class I Genes,H-2 Class I Genes,HLA Class I Genes,Class I Gene,Gene, Class I,Genes, H 2 Class I,H 2 Class I Genes
D005810 Multigene Family A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed) Gene Clusters,Genes, Reiterated,Cluster, Gene,Clusters, Gene,Families, Multigene,Family, Multigene,Gene Cluster,Gene, Reiterated,Multigene Families,Reiterated Gene,Reiterated Genes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Peter Hurt, and Lutz Walter, and Ralf Sudbrak, and Sven Klages, and Ines Müller, and Takashi Shiina, and Hidetoshi Inoko, and Hans Lehrach, and Eberhard Günther, and Richard Reinhardt, and Heinz Himmelbauer
July 2006, Genomics,
Peter Hurt, and Lutz Walter, and Ralf Sudbrak, and Sven Klages, and Ines Müller, and Takashi Shiina, and Hidetoshi Inoko, and Hans Lehrach, and Eberhard Günther, and Richard Reinhardt, and Heinz Himmelbauer
January 1995, Immunogenetics,
Peter Hurt, and Lutz Walter, and Ralf Sudbrak, and Sven Klages, and Ines Müller, and Takashi Shiina, and Hidetoshi Inoko, and Hans Lehrach, and Eberhard Günther, and Richard Reinhardt, and Heinz Himmelbauer
May 2009, Immunogenetics,
Peter Hurt, and Lutz Walter, and Ralf Sudbrak, and Sven Klages, and Ines Müller, and Takashi Shiina, and Hidetoshi Inoko, and Hans Lehrach, and Eberhard Günther, and Richard Reinhardt, and Heinz Himmelbauer
January 1982, Survey of immunologic research,
Peter Hurt, and Lutz Walter, and Ralf Sudbrak, and Sven Klages, and Ines Müller, and Takashi Shiina, and Hidetoshi Inoko, and Hans Lehrach, and Eberhard Günther, and Richard Reinhardt, and Heinz Himmelbauer
March 1979, Transplantation proceedings,
Peter Hurt, and Lutz Walter, and Ralf Sudbrak, and Sven Klages, and Ines Müller, and Takashi Shiina, and Hidetoshi Inoko, and Hans Lehrach, and Eberhard Günther, and Richard Reinhardt, and Heinz Himmelbauer
January 1989, Immunology series,
Peter Hurt, and Lutz Walter, and Ralf Sudbrak, and Sven Klages, and Ines Müller, and Takashi Shiina, and Hidetoshi Inoko, and Hans Lehrach, and Eberhard Günther, and Richard Reinhardt, and Heinz Himmelbauer
February 2008, Journal of dairy science,
Peter Hurt, and Lutz Walter, and Ralf Sudbrak, and Sven Klages, and Ines Müller, and Takashi Shiina, and Hidetoshi Inoko, and Hans Lehrach, and Eberhard Günther, and Richard Reinhardt, and Heinz Himmelbauer
April 2001, Immunogenetics,
Peter Hurt, and Lutz Walter, and Ralf Sudbrak, and Sven Klages, and Ines Müller, and Takashi Shiina, and Hidetoshi Inoko, and Hans Lehrach, and Eberhard Günther, and Richard Reinhardt, and Heinz Himmelbauer
June 1987, Transplantation,
Peter Hurt, and Lutz Walter, and Ralf Sudbrak, and Sven Klages, and Ines Müller, and Takashi Shiina, and Hidetoshi Inoko, and Hans Lehrach, and Eberhard Günther, and Richard Reinhardt, and Heinz Himmelbauer
January 1989, Annales de recherches veterinaires. Annals of veterinary research,
Copied contents to your clipboard!