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The study was undertaken to evaluate immunotoxic effects of cypermethrin administered orally (in ground nut oil) to male albino rats at dose levels (mg/kg) of 0 (control), 5, 10, 20 and 40 once daily for 90 days. Cypermethrin administration produced a significant leucopenia at 40 mg/kg on day 90. A dose dependent decrease (P greater than 0.05) in delayed type hypersensitivity reaction was noticed on day 61 post treatment. Humoral response as evidenced by serum haemagglutinin and haemolysin titres did not show any definite pattern on day 90. However, a significant decrease in spleen weights and significant increase in adrenal weights was recorded in rats receiving the highest test level. Total body weights and liver weights did not show any significant change with any of the dose level studied. Results of the study reveal that low doses (5 and 10 mg/kg) did not have any adverse effect on the immuno-competence of rats.
C Varshneya, and
T Singh, and
L D Sharma, and
H S Bahga, and
S K Garg
June 1988,
Toxicology letters,
C Varshneya, and
T Singh, and
L D Sharma, and
H S Bahga, and
S K Garg
September 1986,
Mutagenesis,
C Varshneya, and
T Singh, and
L D Sharma, and
H S Bahga, and
S K Garg
February 1983,
Xenobiotica; the fate of foreign compounds in biological systems,
C Varshneya, and
T Singh, and
L D Sharma, and
H S Bahga, and
S K Garg
February 2019,
Chemosphere,
C Varshneya, and
T Singh, and
L D Sharma, and
H S Bahga, and
S K Garg
January 2002,
Environmental toxicology and chemistry,
C Varshneya, and
T Singh, and
L D Sharma, and
H S Bahga, and
S K Garg
December 2017,
Fish physiology and biochemistry,
C Varshneya, and
T Singh, and
L D Sharma, and
H S Bahga, and
S K Garg
January 1979,
Journal of environmental pathology and toxicology,
C Varshneya, and
T Singh, and
L D Sharma, and
H S Bahga, and
S K Garg
January 2003,
Letters in applied microbiology,
C Varshneya, and
T Singh, and
L D Sharma, and
H S Bahga, and
S K Garg
January 2008,
Bulletin of environmental contamination and toxicology,
C Varshneya, and
T Singh, and
L D Sharma, and
H S Bahga, and
S K Garg
June 1984,
Archives of dermatology,
