Regulation of ghrelin secretion during pregnancy and lactation in the rat: possible involvement of hypothalamus. 2004

Kazuhiko Shibata, and Hiroshi Hosoda, and Masayasu Kojima, and Kenji Kangawa, and Yasuo Makino, and Ikuko Makino, and Tatsuhiko Kawarabayashi, and Kojiro Futagami, and Yutaka Gomita
Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. kshiba@md.okayama-u.ac.jp

We investigated the plasma concentration of ghrelin peptide during pregnancy and lactation in rats. Plasma ghrelin levels on days 10 and 15 of pregnancy were significantly lower than those of the non-pregnant rats. Thereafter, the plasma ghrelin levels on day 20 of pregnancy sharply increased to levels comparable with those in non-pregnant rats. Ghrelin peptide concentrations in the stomach did not change significantly during pregnancy. In the hypothalamus, ghrelin mRNA levels were significantly lower on day 15 of pregnancy than in the non-pregnant rats. Also, plasma ghrelin levels were significantly lower in lactating dams than non-lactating controls on days 3 and 8 of lactation. We examined the possible involvement of prolactin and oxytocin in the regulation of plasma ghrelin concentrations during lactation. Although plasma prolactin levels were decreased by the administration of bromocriptine, plasma ghrelin levels did not differ significantly between vehicle- and drug-treated lactating rats. Administration of haloperidol produced a marked increase in plasma prolactin levels as compared with the non-lactating controls. However, plasma ghrelin levels were not significantly different between vehicle- and drug-treated rats. Administration of an oxytocin antagonist into the lateral ventricle significantly inhibited the increase in the plasma oxytocin level induced by acute suckling. However, plasma ghrelin levels did not significantly between the groups. These observations indicated that the decrease in serum ghrelin is caused by a loss of the contribution of hypothalamic ghrelin. Furthermore, the present results suggested that the suckling stimulus itself, but the release of prolactin or oxytocin, is the factor most likely to be responsible for the suppression of ghrelin secretion during lactation.

UI MeSH Term Description Entries
D007031 Hypothalamus Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE. Lamina Terminalis,Preoptico-Hypothalamic Area,Area, Preoptico-Hypothalamic,Areas, Preoptico-Hypothalamic,Preoptico Hypothalamic Area,Preoptico-Hypothalamic Areas
D007774 Lactation The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN. Lactation, Prolonged,Milk Secretion,Lactations, Prolonged,Milk Secretions,Prolonged Lactation,Prolonged Lactations
D010121 Oxytocin A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION. Ocytocin,Pitocin,Syntocinon
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011270 Pregnancy, Animal The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH. Animal Pregnancies,Animal Pregnancy,Pregnancies, Animal
D011388 Prolactin A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate. Lactogenic Hormone, Pituitary,Mammotropic Hormone, Pituitary,Mammotropin,PRL (Prolactin),Hormone, Pituitary Lactogenic,Hormone, Pituitary Mammotropic,Pituitary Lactogenic Hormone,Pituitary Mammotropic Hormone
D001971 Bromocriptine A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion. 2-Bromoergocryptine,Bromocryptin,2-Bromo-alpha-ergocryptine,2-Bromo-alpha-ergokryptine,2-Bromoergocryptine Mesylate,2-Bromoergocryptine Methanesulfonate,2-Bromoergokryptine,Bromocriptin,Bromocriptine Mesylate,CB-154,Parlodel,2 Bromo alpha ergocryptine,2 Bromo alpha ergokryptine,2 Bromoergocryptine,2 Bromoergocryptine Mesylate,2 Bromoergocryptine Methanesulfonate,2 Bromoergokryptine,CB 154,CB154,Mesylate, 2-Bromoergocryptine,Mesylate, Bromocriptine,Methanesulfonate, 2-Bromoergocryptine
D005260 Female Females
D005753 Gastric Mucosa Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones. Cardiac Glands,Gastric Glands,Pyloric Glands,Cardiac Gland,Gastric Gland,Gastric Mucosas,Gland, Cardiac,Gland, Gastric,Gland, Pyloric,Glands, Cardiac,Glands, Gastric,Glands, Pyloric,Mucosa, Gastric,Mucosas, Gastric,Pyloric Gland
D006220 Haloperidol A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279) Haldol

Related Publications

Kazuhiko Shibata, and Hiroshi Hosoda, and Masayasu Kojima, and Kenji Kangawa, and Yasuo Makino, and Ikuko Makino, and Tatsuhiko Kawarabayashi, and Kojiro Futagami, and Yutaka Gomita
April 1981, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
Kazuhiko Shibata, and Hiroshi Hosoda, and Masayasu Kojima, and Kenji Kangawa, and Yasuo Makino, and Ikuko Makino, and Tatsuhiko Kawarabayashi, and Kojiro Futagami, and Yutaka Gomita
January 2001, Progress in brain research,
Kazuhiko Shibata, and Hiroshi Hosoda, and Masayasu Kojima, and Kenji Kangawa, and Yasuo Makino, and Ikuko Makino, and Tatsuhiko Kawarabayashi, and Kojiro Futagami, and Yutaka Gomita
May 1967, The Journal of physiology,
Kazuhiko Shibata, and Hiroshi Hosoda, and Masayasu Kojima, and Kenji Kangawa, and Yasuo Makino, and Ikuko Makino, and Tatsuhiko Kawarabayashi, and Kojiro Futagami, and Yutaka Gomita
January 2008, Vitamins and hormones,
Kazuhiko Shibata, and Hiroshi Hosoda, and Masayasu Kojima, and Kenji Kangawa, and Yasuo Makino, and Ikuko Makino, and Tatsuhiko Kawarabayashi, and Kojiro Futagami, and Yutaka Gomita
October 1985, Biochemical Society transactions,
Kazuhiko Shibata, and Hiroshi Hosoda, and Masayasu Kojima, and Kenji Kangawa, and Yasuo Makino, and Ikuko Makino, and Tatsuhiko Kawarabayashi, and Kojiro Futagami, and Yutaka Gomita
June 1981, The Journal of endocrinology,
Kazuhiko Shibata, and Hiroshi Hosoda, and Masayasu Kojima, and Kenji Kangawa, and Yasuo Makino, and Ikuko Makino, and Tatsuhiko Kawarabayashi, and Kojiro Futagami, and Yutaka Gomita
March 2003, Journal of neuroendocrinology,
Kazuhiko Shibata, and Hiroshi Hosoda, and Masayasu Kojima, and Kenji Kangawa, and Yasuo Makino, and Ikuko Makino, and Tatsuhiko Kawarabayashi, and Kojiro Futagami, and Yutaka Gomita
December 1984, Archivos de biologia y medicina experimentales,
Kazuhiko Shibata, and Hiroshi Hosoda, and Masayasu Kojima, and Kenji Kangawa, and Yasuo Makino, and Ikuko Makino, and Tatsuhiko Kawarabayashi, and Kojiro Futagami, and Yutaka Gomita
November 1956, Gigiena i sanitariia,
Kazuhiko Shibata, and Hiroshi Hosoda, and Masayasu Kojima, and Kenji Kangawa, and Yasuo Makino, and Ikuko Makino, and Tatsuhiko Kawarabayashi, and Kojiro Futagami, and Yutaka Gomita
July 2005, Journal of neuroendocrinology,
Copied contents to your clipboard!