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Reference ranges for four hematological parameters--hemoglobin, hematocrit, white blood cell and platelet count--in each gestation were established from values for fetal blood samples obtained by cordocentesis from 72 pregnancies at 16-39 weeks gestation. These 72 fetuses turned out as normal or single malformations which should not affect fetal hematological values. Significant correlations were observed between hemoglobin, hematocrit and platelet counts and the number of weeks of gestation. No correlation was found between the white blood cell count and gestational age. Fetal anemia (hematocrit was below the lower limit of the 95% confidence interval) was found in 18 (7%) of all the fetuses that underwent cordocentesis, including nonimmune hydrops fetalis (8 cases), Rh isoimmunization (4 cases), twin-to-twin transfusion syndrome (3 cases), trisomy 18 (2 cases) and autoimmune thrombocytopenia (1 case). Of 26 hydropic fetuses, 8 (31%) were anemic. The prognosis of those fetuses depended on either the gestational age or the severity of the fetal anemia. Our results are useful in diagnosing fetal hematological disorders and to make decisions for fetal therapy.
J Murotsuki, and
K Okamura, and
M Iwamoto, and
S Kosuge, and
Y Kimura, and
M Kobayashi, and
Y Takeyama, and
M Yano, and
A Yajima
November 1988,
Nihon Sanka Fujinka Gakkai zasshi,
J Murotsuki, and
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Y Takeyama, and
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A Yajima
January 1993,
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J Murotsuki, and
K Okamura, and
M Iwamoto, and
S Kosuge, and
Y Kimura, and
M Kobayashi, and
Y Takeyama, and
M Yano, and
A Yajima
January 1986,
Fetal therapy,
J Murotsuki, and
K Okamura, and
M Iwamoto, and
S Kosuge, and
Y Kimura, and
M Kobayashi, and
Y Takeyama, and
M Yano, and
A Yajima
January 1999,
The Turkish journal of pediatrics,
J Murotsuki, and
K Okamura, and
M Iwamoto, and
S Kosuge, and
Y Kimura, and
M Kobayashi, and
Y Takeyama, and
M Yano, and
A Yajima
August 1990,
American journal of obstetrics and gynecology,
J Murotsuki, and
K Okamura, and
M Iwamoto, and
S Kosuge, and
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M Kobayashi, and
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M Yano, and
A Yajima
July 1990,
American journal of obstetrics and gynecology,
J Murotsuki, and
K Okamura, and
M Iwamoto, and
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Y Kimura, and
M Kobayashi, and
Y Takeyama, and
M Yano, and
A Yajima
February 1990,
Prenatal diagnosis,
J Murotsuki, and
K Okamura, and
M Iwamoto, and
S Kosuge, and
Y Kimura, and
M Kobayashi, and
Y Takeyama, and
M Yano, and
A Yajima
August 2004,
Prenatal diagnosis,
J Murotsuki, and
K Okamura, and
M Iwamoto, and
S Kosuge, and
Y Kimura, and
M Kobayashi, and
Y Takeyama, and
M Yano, and
A Yajima
August 1989,
American journal of obstetrics and gynecology,
J Murotsuki, and
K Okamura, and
M Iwamoto, and
S Kosuge, and
Y Kimura, and
M Kobayashi, and
Y Takeyama, and
M Yano, and
A Yajima
October 1997,
Prenatal diagnosis,
