Biomaterial Database

[Current views on stunned and hibernating myocardium]. 2003

Kornél Simon, and István Czuriga

Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Altalános Orvostudományi Kar, Tùdó-Szív Klinika. kornelsimon@datatrans.hu

A short review is presented about similarities and dissimilarities in pathophysiology of prompt reversible ischemia, stunned and hibernating myocardium. Definitions of these entities are given. Characteristics of clinical appearance, diagnostic procedures, natural history, prognosis and therapeutic modalities of stunned and hibernating myocardium are reviewed, respectively. Interrelations between prompt reversible ischemia, stunned, hibernating myocardium and ischemic preconditioning are briefly reported.

UI	MeSH Term	Description	Entries
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D017202	Myocardial Ischemia	A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).	Heart Disease, Ischemic,Ischemia, Myocardial,Ischemic Heart Disease,Disease, Ischemic Heart,Diseases, Ischemic Heart,Heart Diseases, Ischemic,Ischemias, Myocardial,Ischemic Heart Diseases,Myocardial Ischemias
D017682	Myocardial Stunning	Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.	Hibernation, Myocardial,Myocardial Hibernation,Stunned Myocardium,Myocardium, Stunned,Stunning, Myocardial
D019157	Ischemic Preconditioning, Myocardial	Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. The period of pre-exposure and the number of times the tissue is exposed to ischemia and reperfusion vary, the average being 3 to 5 minutes.	Myocardial Preconditioning,Myocardial Ischemic Preconditioning,Preconditioning, Myocardial,Preconditioning, Myocardial Ischemic