Biomaterial Database

Preface. Virus gene silencing by RNA interference. 2004

Susana López, and Carlos F Arias

Dept. de Genetica del Desarrollo y Fisiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Avenida Universidad 2001, Col. Chamilpa, Cuernavaca, Morelos 62210, Mexico. susana@ibt.unam.mx

UI	MeSH Term	Description	Entries
D005814	Genes, Viral	The functional hereditary units of VIRUSES.	Viral Genes,Gene, Viral,Viral Gene
D012330	RNA, Double-Stranded	RNA consisting of two strands as opposed to the more prevalent single-stranded RNA. Most of the double-stranded segments are formed from transcription of DNA by intramolecular base-pairing of inverted complementary sequences separated by a single-stranded loop. Some double-stranded segments of RNA are normal in all organisms.	Double-Stranded RNA,Double Stranded RNA,RNA, Double Stranded
D014780	Viruses	Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells.	Animal Viruses,Zoophaginae,Animal Virus,Virus,Virus, Animal,Viruses, Animal
D043244	Ribonuclease III	An endoribonuclease that is specific for double-stranded RNA. It plays a role in POST-TRANSCRIPTIONAL RNA PROCESSING of pre-RIBOSOMAL RNA and a variety of other RNA structures that contain double-stranded regions.	Dicer Enzyme,RNase D,RNase III,Ribonuclease D,Enzyme, Dicer
D018406	Virus Physiological Phenomena	Biological properties, processes, and activities of VIRUSES, including the interactions with the cells they infect.	Viral Physiological Processes,Viral Physiology,Virus Physiological Processes,Physiology, Viral,Viral Physiological Concepts,Viral Physiological Phenomena,Viral Physiological Process,Virus Physiological Concepts,Virus Physiological Phenomenon,Virus Physiological Process,Virus Physiology,Concept, Viral Physiological,Concept, Virus Physiological,Concepts, Viral Physiological,Concepts, Virus Physiological,Phenomena, Viral Physiological,Phenomena, Virus Physiological,Phenomenon, Virus Physiological,Phenomenons, Virus Physiological,Physiological Process, Viral,Physiological Process, Virus,Physiological Processes, Viral,Physiological Processes, Virus,Physiology, Virus,Process, Viral Physiological,Process, Virus Physiological,Processes, Viral Physiological,Processes, Virus Physiological,Viral Physiological Concept,Virus Physiological Concept
D020868	Gene Silencing	Interruption or suppression of the expression of a gene at transcriptional or translational levels.	Gene Inactivation,Inactivation, Gene,Silencing, Gene
D020871	RNA Stability	The extent to which an RNA molecule retains its structural integrity and resists degradation by RNASE, and base-catalyzed HYDROLYSIS, under changing in vivo or in vitro conditions.	RNA Decay,mRNA Decay,mRNA Transcript Degradation,RNA Degradation,RNA Instability,mRNA Degradation,mRNA Instability,mRNA Stability,Decay, RNA,Decay, mRNA,Degradation, RNA,Degradation, mRNA,Degradation, mRNA Transcript,Instability, RNA,Instability, mRNA,Stability, RNA,Stability, mRNA,Transcript Degradation, mRNA
D034622	RNA Interference	A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.	Gene Silencing, Post-Transcriptional,Post-Transcriptional Gene Silencing,Co-Suppression,Cosuppression,Posttranscriptional Gene Silencing,RNA Silencing,RNAi,Co Suppression,Gene Silencing, Post Transcriptional,Gene Silencing, Posttranscriptional,Gene Silencings, Posttranscriptional,Interference, RNA,Post Transcriptional Gene Silencing,Post-Transcriptional Gene Silencings,Silencing, Post-Transcriptional Gene
D034741	RNA, Small Interfering	Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.	RNA, Scan,Repeat-Associated siRNA,Scan RNA,Small Scan RNA,Trans-Acting siRNA,siRNA,siRNA, Repeat-Associated,siRNA, Trans-Acting,Short Hairpin RNA,Short Interfering RNA,Small Hairpin RNA,Small Interfering RNA,scnRNA,shRNA,tasiRNA,Hairpin RNA, Short,Hairpin RNA, Small,Interfering RNA, Short,Interfering RNA, Small,RNA, Short Hairpin,RNA, Short Interfering,RNA, Small Hairpin,RNA, Small Scan,Repeat Associated siRNA,Scan RNA, Small,Trans Acting siRNA,siRNA, Repeat Associated,siRNA, Trans Acting
D034743	RNA-Induced Silencing Complex	A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA).	RISC Multicomponent Nuclease,Complex, RNA-Induced Silencing,Multicomponent Nuclease, RISC,Nuclease, RISC Multicomponent,RNA Induced Silencing Complex,Silencing Complex, RNA-Induced