BIOMAT Database Logo BIOMAT Database Logo

Mixed chimerism and transplantation tolerance. 2004

A Benedict Cosimi, and David H Sachs
Transplantation Unit of the General Surgical Service, and the Transplantation Biology Research Center, Massachusetts General Hospital, and the Department of Surgery, Harvard Medical School, Boston, USA.

Establishment of mixed hematopoietic chimerism carries with it the induction of transplantation tolerance to any other tissue or organ from the same donor. This strategy has been studied extensively for induction of tolerance in mice. During the past decade, we have extended the same strategy, with modifications, to cynomolgus monkeys and most recently to renal transplant patients. In this report we review the evolution of these studies from preclinical applications to our current clinical experience with two therapeutic protocols sponsored by the Immune Tolerance Network. The first of these studies is for patients with myeloma and end-stage renal disease with an HLA-matched sibling donor; the second for patients with end-stage renal disease and HLA-mismatched donors. Although it is still early in the course of these studies, the results to date are very encouraging.

UI MeSH Term Description Entries
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008252 Macaca fascicularis A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula. Burmese Long-Tailed Macaque,Crab-Eating Monkey,Cynomolgus Monkey,M. f. aurea,M. fascicularis,Macaca fascicularis aurea,Monkey, Crab-Eating,Monkey, Cynomolgus,Crab-Eating Macaque,Burmese Long Tailed Macaque,Crab Eating Macaque,Crab Eating Monkey,Crab-Eating Macaques,Crab-Eating Monkeys,Cynomolgus Monkeys,Long-Tailed Macaque, Burmese,Macaque, Burmese Long-Tailed,Macaque, Crab-Eating,Monkey, Crab Eating
D006650 Histocompatibility Testing Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed) Crossmatching, Tissue,HLA Typing,Tissue Typing,Crossmatchings, Tissue,HLA Typings,Histocompatibility Testings,Testing, Histocompatibility,Testings, Histocompatibility,Tissue Crossmatching,Tissue Crossmatchings,Tissue Typings,Typing, HLA,Typing, Tissue,Typings, HLA,Typings, Tissue
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014019 Tissue Donors Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients. Organ Donors,Donors,Ovum Donors,Semen Donors,Transplant Donors,Donor,Donor, Organ,Donor, Ovum,Donor, Semen,Donor, Tissue,Donor, Transplant,Donors, Organ,Donors, Ovum,Donors, Semen,Donors, Tissue,Donors, Transplant,Organ Donor,Ovum Donor,Semen Donor,Tissue Donor,Transplant Donor
D014183 Transplantation, Heterologous Transplantation between animals of different species. Xenotransplantation,Heterograft Transplantation,Heterografting,Heterologous Transplantation,Xenograft Transplantation,Xenografting,Transplantation, Heterograft,Transplantation, Xenograft
D016030 Kidney Transplantation The transference of a kidney from one human or animal to another. Grafting, Kidney,Renal Transplantation,Transplantation, Kidney,Transplantation, Renal,Kidney Grafting,Kidney Transplantations,Renal Transplantations,Transplantations, Kidney,Transplantations, Renal
D018183 Transplantation Chimera An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE. Chimera, Transplantation,Chimeras, Transplantation,Transplantation Chimeras
D023001 Transplantation Tolerance An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. Graft Tolerance,Allograft Tolerance,Tolerance, Allograft,Tolerance, Graft,Tolerance, Transplantation

Related Publications

A Benedict Cosimi, and David H Sachs
Mixed chimerism and transplantation tolerance.
January 2001, Annual review of medicine,
A Benedict Cosimi, and David H Sachs
Transplantation tolerance through mixed chimerism.
October 2010, Nature reviews. Nephrology,
A Benedict Cosimi, and David H Sachs
Mixed hematopoietic chimerism and transplantation tolerance.
January 1997, Immunologic research,
A Benedict Cosimi, and David H Sachs
Transplantation tolerance induced by mixed chimerism.
August 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
A Benedict Cosimi, and David H Sachs
Mixed chimerism as an approach to transplantation tolerance.
April 2000, Clinical immunology (Orlando, Fla.),
A Benedict Cosimi, and David H Sachs
On minor histocompatibility antigens, mixed chimerism, and transplantation tolerance.
March 2021, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
A Benedict Cosimi, and David H Sachs
Mixed chimerism to induce tolerance for solid organ transplantation.
April 1991, Journal of pediatric surgery,
A Benedict Cosimi, and David H Sachs
Mixed allogeneic chimerism as an approach to transplantation tolerance.
January 1988, Immunology today,
A Benedict Cosimi, and David H Sachs
Transplantation tolerance through mixed chimerism: From allo to xeno.
May 2018, Xenotransplantation,
A Benedict Cosimi, and David H Sachs
Clinical experience with mixed chimerism to induce transplantation tolerance.
December 2008, Transplant international : official journal of the European Society for Organ Transplantation,
Copied contents to your clipboard!