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Marked neuron loss in the predominantly serotonergic nucleus raphes dorsalis (NRd) in Alzheimer's disease (AD) has repeatedly been reported in the literature. However, most of these studies quantitated only part of the NRd and data were expressed as numerical density. Applying a 3-dimensional sampling scheme throughout the entire rostrocaudal extent of the NRd and sampling neurons regardless of their size and staining characteristics, an overall neuron loss of 39.4% was demonstrated and a tendency for cell shrinkage was likely to be present. No rostrocaudal gradient in neuron loss could be shown. These NRd data are in accordance with neuron loss in other subcortical structures in AD.
M A Aletrino, and
O J Vogels, and
P H Van Domburg, and
H J Ten Donkelaar
January 1981,
Acta histochemica,
M A Aletrino, and
O J Vogels, and
P H Van Domburg, and
H J Ten Donkelaar
June 1985,
Annals of neurology,
M A Aletrino, and
O J Vogels, and
P H Van Domburg, and
H J Ten Donkelaar
January 1980,
Acta histochemica,
M A Aletrino, and
O J Vogels, and
P H Van Domburg, and
H J Ten Donkelaar
January 1986,
Acta histochemica,
M A Aletrino, and
O J Vogels, and
P H Van Domburg, and
H J Ten Donkelaar
November 1981,
Bollettino della Societa italiana di biologia sperimentale,
M A Aletrino, and
O J Vogels, and
P H Van Domburg, and
H J Ten Donkelaar
April 1993,
Brain research,
M A Aletrino, and
O J Vogels, and
P H Van Domburg, and
H J Ten Donkelaar
November 1986,
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques,
M A Aletrino, and
O J Vogels, and
P H Van Domburg, and
H J Ten Donkelaar
January 1990,
Neurobiology of aging,
M A Aletrino, and
O J Vogels, and
P H Van Domburg, and
H J Ten Donkelaar
June 1997,
Neuroscience,
M A Aletrino, and
O J Vogels, and
P H Van Domburg, and
H J Ten Donkelaar
May 1984,
Annals of neurology,
