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Male ddY mice were exposed to ethylene oxide (EO) at a concentration of 400 ppm, 6 hours a day, 3 days a week for 13 weeks and the effects of EO on the hepatic drug metabolizing enzymes were investigated. The liver and spleen weight per body weight did not change. Compared to the control group, the kidney weight of the exposed group increased while the testis weight decreased significantly. Hematological examination showed macrocytic anemia in the exposed group. Contents of microsomal cytochrome P-450 in the exposed group increased twice as much as that in the control group, while microsomal protein, cytochrome b5, protoheme and NADPH-cytochrome C reductase activity did not change. NADH-ferricyanide reductase activity of the exposed group increased significantly. Among the glutathione related enzymes in the liver, glutathione reductase and glutathione peroxidase activities in the exposed group decreased but glutathione-S-transferase activity increased significantly.
K Fujishiro, and
N Inoue, and
K Mori, and
K Imazu
December 1984,
Toxicology and applied pharmacology,
K Fujishiro, and
N Inoue, and
K Mori, and
K Imazu
December 1987,
Toxicology and applied pharmacology,
K Fujishiro, and
N Inoue, and
K Mori, and
K Imazu
February 1974,
Toxicology and applied pharmacology,
K Fujishiro, and
N Inoue, and
K Mori, and
K Imazu
May 1982,
Toxicology and applied pharmacology,
K Fujishiro, and
N Inoue, and
K Mori, and
K Imazu
August 1988,
Research communications in chemical pathology and pharmacology,
K Fujishiro, and
N Inoue, and
K Mori, and
K Imazu
July 1969,
Surgery, gynecology & obstetrics,
K Fujishiro, and
N Inoue, and
K Mori, and
K Imazu
February 2005,
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases,
K Fujishiro, and
N Inoue, and
K Mori, and
K Imazu
January 1992,
Drug and chemical toxicology,
K Fujishiro, and
N Inoue, and
K Mori, and
K Imazu
May 1979,
British journal of cancer,
K Fujishiro, and
N Inoue, and
K Mori, and
K Imazu
January 1986,
Environmental mutagenesis,
