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A study of human articular cartilage indicated that componenet proteoglycans can be phosphorylated. Phosphorylation, also found in a specimen of human epiphysial cartilage, occurred when [gamma-32P]-ATP or 32Pi was included in the in vitro incubation medium. Treatment of the phosphorylated proteoglycans with chondroitinase and chondrosulfatases effectively removed the chondroitin sulfate without dephosphorylating the remaining molecule. Since phosphorylation could be effected in a totally chemically defined medium, it appears that the necessary enzyme systems for this reaction are contained entirely within chondrocytes.
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