Update of implantable cardioverter/defibrillator and cardiac resynchronization therapy in heart failure. 2004

Tapan Rami, and Hue-Teh Shih
Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.

OBJECTIVE Heart failure prevalence is reaching epidemic proportion in the United States and is associated with significant morbidity and mortality. A large proportion of the mortality is the result of sudden cardiac death (SCD). Clinical trials have demonstrated the superiority of the implantable cardioverter/defibrillator (ICD) compared with antiarrhythmic drugs for secondary prevention of sudden cardiac death. RESULTS Recently, several clinical trials in primary prevention of sudden cardiac death in both ischemic and nonischemic heart failure have been completed. The 2002 guidelines for implantable cardioverter/defibrillator implantation were recently released as well. Adjunct therapy consisting of antiarrhythmic drugs or radiofrequency ablation is necessary in the subset of patients with implantable cardioverter/defibrillator that have frequent or intractable ventricular arrhythmias. An emerging new therapy in the heart failure population is cardiac resynchronization therapy, which coordinates right and left ventricular pacing in a subset of patients with interventricular conduction delay. CONCLUSIONS Several randomized clinical trials have demonstrated improvements in heart failure-related symptoms, exercise tolerance, and reversal of ventricular remodeling. Meta-analysis of these trials has also demonstrated mortality benefit. Patient selection, left ventricular pacing site, and optimal device programming are issues that need further investigation. Recent trials have also studied the compatibility between cardiac resynchronization therapy and implantable cardioverter/defibrillator as a single device. Finally, the DAVID trial has raised concerns of conventional right ventricular pacing and the risk of heart failure in a subset of patients.

UI MeSH Term Description Entries
D006333 Heart Failure A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION. Cardiac Failure,Heart Decompensation,Congestive Heart Failure,Heart Failure, Congestive,Heart Failure, Left-Sided,Heart Failure, Right-Sided,Left-Sided Heart Failure,Myocardial Failure,Right-Sided Heart Failure,Decompensation, Heart,Heart Failure, Left Sided,Heart Failure, Right Sided,Left Sided Heart Failure,Right Sided Heart Failure
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016032 Randomized Controlled Trials as Topic Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table. Clinical Trials, Randomized,Controlled Clinical Trials, Randomized,Trials, Randomized Clinical
D016757 Death, Sudden, Cardiac Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005) Cardiac Sudden Death,Sudden Cardiac Death,Cardiac Arrest, Sudden,Sudden Cardiac Arrest,Arrest, Sudden Cardiac,Cardiac Arrests, Sudden,Cardiac Death, Sudden,Death, Cardiac Sudden,Death, Sudden Cardiac,Sudden Death, Cardiac
D017147 Defibrillators, Implantable Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes. Cardioverter-Defibrillators, Implantable,Implantable Cardioverter Defibrillator,Implantable Cardioverter-Defibrillators,Implantable Defibrillators,Cardioverter Defibrillator, Implantable,Cardioverter Defibrillators, Implantable,Cardioverter-Defibrillator, Implantable,Defibrillator, Implantable,Defibrillator, Implantable Cardioverter,Defibrillators, Implantable Cardioverter,Implantable Cardioverter Defibrillators,Implantable Cardioverter-Defibrillator,Implantable Defibrillator

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