[Mortality in children with epilepsy. A clinical prospective study]. 2004

M Devilat Barros, and G Rivera Gómez, and V Gómez Muñoz, and J P Sepulveda Olmos
Hospital de Niños Luis Calvo Mackenna, Santiago de Chile, Chile.

BACKGROUND Mortality in patients with epilepsy is higher than the general population, but the data about children is not too extends. OBJECTIVES. To determine the risk of dying in epileptic children, the associated factors and the cause of death, as well as to target the support given to the family. METHODS From 1996 to 2002, sixteen children with epilepsy controlled in our centre died. Fifteen of them were included in our research according to a previous protocol. The data was token from our data bank, the clinical file and parents interview. RESULTS The standard mortality rate was 3.21 (95% CI: 1.48 4.95). The main group had an early onset on their illness. Thirteen children had remote symptomatic epilepsy. Eleven had resistant or catastrophic epilepsy. The EEG was specific for epilepsy in 11 cases. Nine children were receiving politherapy. Eight patients had received three or more therapeutic schemes. Eight had pre mortem therapeutic blood levels of antiepileptic drugs. Ten patients die because of infection and five because of a sudden unexpected death. In one of them the sudden unexpected death was definite and was given in a pregnant teenager with a juvenile myoclonic epilepsy. Other boy died soon after an earthquake. The assistance to the mourning elaboration was useful for the family. CONCLUSIONS This children has a high risk of dying, it is associated to on early onset of severe, active, resistant and catastrophic epilepsy. The entire control of crisis should be the main target of treatment.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007239 Infections Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases. Infection,Infection and Infestation,Infections and Infestations,Infestation and Infection,Infestations and Infections
D008297 Male Males
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011248 Pregnancy Complications Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases. Adverse Birth Outcomes,Complications, Pregnancy,Adverse Birth Outcome,Birth Outcome, Adverse,Complication, Pregnancy,Outcome, Adverse Birth,Pregnancy Complication
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D002423 Cause of Death Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint. Causes of Death,Death Cause,Death Causes
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children

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