Impaired place navigation in place and matching-to-place swimming pool tasks follows both retrosplenial cortex lesions and cingulum bundle lesions in rats. 2004

K Troy Harker, and Ian Q Whishaw
Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada. kharker@dal.ca

The retrosplenial (RS) cortex (area 29) and the adjacent cingulum bundle (CG) are components of neural circuits that include the hippocampus. Given the evidence suggesting that the hippocampus plays a central role in spatial navigation, several lines of investigation have examined the possible contributions of these structures to spatial navigation. The combined and/or separate contributions of these structures have been difficult to establish because their close proximity usually results in combined injury after lesions and because there have been conflicting results related to lesion type and the strain of rat subjects. The purpose of the present study was to compare the effects of selective CG damage with selective RS damage in Long-Evans rats, a domestic rat strain that displays superior spatial skills, and by using spatial behavior assessment procedures that are sensitive to CG damage. Rats with cytotoxic N-methyl-D-aspartate (NMDA) RS lesions or surgical CG transection were tested on two spatial tasks in the Morris water task; a place learning task, sensitive to nonspatial and spatial behavior, and a matching-to-place task, sensitive to spatial behavior. Both the RS and CG groups were impaired on most measures relative to the control group on both the place task and the matching-to-place task. The results are discussed in relation to the anatomical organization of CG and RG projections to the hippocampus and with respect to their possible separate/conjoint contributions to spatial behavior.

UI MeSH Term Description Entries
D008297 Male Males
D009415 Nerve Net A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction. Neural Networks (Anatomic),Nerve Nets,Net, Nerve,Nets, Nerve,Network, Neural (Anatomic),Networks, Neural (Anatomic),Neural Network (Anatomic)
D009949 Orientation Awareness of oneself in relation to time, place and person. Cognitive Orientation,Mental Orientation,Psychological Orientation,Cognitive Orientations,Mental Orientations,Orientation, Cognitive,Orientation, Mental,Orientation, Psychological,Orientations,Orientations, Cognitive,Orientations, Mental,Orientations, Psychological,Psychological Orientations
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013028 Space Perception The awareness of the spatial properties of objects; includes physical space. Perception, Space,Perceptions, Space,Space Perceptions
D016194 Receptors, N-Methyl-D-Aspartate A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity. N-Methyl-D-Aspartate Receptor,N-Methyl-D-Aspartate Receptors,NMDA Receptor,NMDA Receptor-Ionophore Complex,NMDA Receptors,Receptors, NMDA,N-Methylaspartate Receptors,Receptors, N-Methylaspartate,N Methyl D Aspartate Receptor,N Methyl D Aspartate Receptors,N Methylaspartate Receptors,NMDA Receptor Ionophore Complex,Receptor, N-Methyl-D-Aspartate,Receptor, NMDA,Receptors, N Methyl D Aspartate,Receptors, N Methylaspartate
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D018782 Maze Learning Learning the correct route through a maze to obtain reinforcement. It is used for human or animal populations. (Thesaurus of Psychological Index Terms, 6th ed) Maze Test,Learning, Maze,Maze Learnings,Maze Tests
D020318 Rats, Long-Evans An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively. Long-Evans Rat,Long Evans Rats,Evans Rats, Long,Long Evans Rat,Long-Evans Rats,Rat, Long-Evans,Rats, Long Evans

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