[Review of the value of BCG maintenance therapy in superficial bladder tumours]. 2004

Michaël Peyromaure, and Marc Zerbib
Service d'Urologie, Hôpital Cochin, Paris, France. michael.peuromaure@cch.ap-hop-paris.fr

This article reviews the benefits of BCG maintenance therapy in ment patients with superficial bladder tumours. The rare published studies conclude on contradictory results. These differences can probably be explained by the variability of the protocols used, the small number of patients included, and the heterogeneity of the series (presenting tumours of different stages and grades). In the largest series, that reported by the Southwest Oncology Group SWOG), maintenance therapy significantly reduced the risk of tumour recurrence and progression in carcinomas in situ and recurrent Ta or T1 tumours. The treatment recommended by the SWOG consists of a weekly instillation for 3 weeks 3, 6, 12, 18, 24, 30 and 36 months after induction therapy.

UI MeSH Term Description Entries
D001749 Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER. Bladder Cancer,Bladder Neoplasms,Cancer of Bladder,Bladder Tumors,Cancer of the Bladder,Malignant Tumor of Urinary Bladder,Neoplasms, Bladder,Urinary Bladder Cancer,Bladder Cancers,Bladder Neoplasm,Bladder Tumor,Cancer, Bladder,Cancer, Urinary Bladder,Neoplasm, Bladder,Neoplasm, Urinary Bladder,Tumor, Bladder,Tumors, Bladder,Urinary Bladder Neoplasm
D002295 Carcinoma, Transitional Cell A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS. Carcinomas, Transitional Cell,Cell Carcinoma, Transitional,Cell Carcinomas, Transitional,Transitional Cell Carcinoma,Transitional Cell Carcinomas
D002985 Clinical Protocols Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy. Protocols, Clinical,Research Protocols, Clinical,Treatment Protocols,Clinical Protocol,Clinical Research Protocol,Clinical Research Protocols,Protocol, Clinical,Protocol, Clinical Research,Protocols, Clinical Research,Protocols, Treatment,Research Protocol, Clinical,Treatment Protocol
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000276 Adjuvants, Immunologic Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. Immunoactivators,Immunoadjuvant,Immunoadjuvants,Immunologic Adjuvant,Immunopotentiator,Immunopotentiators,Immunostimulant,Immunostimulants,Adjuvant, Immunologic,Adjuvants, Immunological,Immunologic Adjuvants,Immunological Adjuvant,Adjuvant, Immunological,Immunological Adjuvants
D001500 BCG Vaccine An active immunizing agent and a viable avirulent attenuated strain of MYCOBACTERIUM BOVIS, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity. Bacillus Calmette Guerin Vaccine,Calmette Guerin Bacillus Vaccine,Calmette's Vaccine,Calmette Vaccine,Calmettes Vaccine,Vaccine, BCG,Vaccine, Calmette's

Related Publications

Michaël Peyromaure, and Marc Zerbib
January 1991, International urology and nephrology,
Michaël Peyromaure, and Marc Zerbib
January 1992, European urology,
Michaël Peyromaure, and Marc Zerbib
January 1992, International urology and nephrology,
Michaël Peyromaure, and Marc Zerbib
January 1989, Progress in clinical and biological research,
Michaël Peyromaure, and Marc Zerbib
February 1998, Bulletin du cancer,
Michaël Peyromaure, and Marc Zerbib
September 1998, Hinyokika kiyo. Acta urologica Japonica,
Michaël Peyromaure, and Marc Zerbib
February 2001, Oncology (Williston Park, N.Y.),
Michaël Peyromaure, and Marc Zerbib
January 2001, Oncology (Williston Park, N.Y.),
Michaël Peyromaure, and Marc Zerbib
January 1991, In vivo (Athens, Greece),
Copied contents to your clipboard!