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Safety and efficacy of a NRTI-sparing HAART regimen of efavirenz and lopinavir/ritonavir in HIV-1-infected children. 2004
Pieter L A Fraaij, and
Jennifer Neubert, and
Alina S Bergshoeff, and
Annemarie M C van Rossum, and
Nico G Hartwig, and
Horst Schroten, and
Klaus Korn, and
David M Burger, and
Ronald de Groot, and
Tim Niehues
Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, the Netherlands.
We studied a nucleoside reverse transcriptase inhibitor (NRTI)-sparing regimen for the treatment of children infected with NRTI-resistant HIV-1. The combination of lopinavir/ritonavir and efavirenz suppressed HIV-1 levels for a prolonged period and resulted in a significant increase in CD4+ T cell numbers despite an extensive prior treatment with NRTI (>4 years). Observed side effects were transient with the exception of dyslipidaemia.
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