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Previously we have shown low levels of dystrophin immunoreactivity in muscle from patients with DMD. According to the "frame-shift hypothesis" DMD muscle should not synthesize any dystrophin through to the C-terminus and it has been suggested that the protein detected is not dystrophin, but a related autosomal homologue. We have labelled serial sections of DMD muscle with specific monoclonal antibodies to the amino, rod and C-terminal domains of dystrophin and find labelling on the same individual fibres, allowing us to conclude that the protein detected is Xp21-encoded dystrophin. This has an impact on the interpretation of myoblast transfer experiments. The abundance (on blots) of "C-terminal dystrophin" appears lower than "rod dystrophin" in both BMD and DMD.
L V Nicholson, and
M A Johnson, and
K Davison, and
E O'Donnell, and
G Falkous, and
M Barron, and
J B Harris
November 1989,
Seikagaku. The Journal of Japanese Biochemical Society,
L V Nicholson, and
M A Johnson, and
K Davison, and
E O'Donnell, and
G Falkous, and
M Barron, and
J B Harris
January 1989,
Neuron,
L V Nicholson, and
M A Johnson, and
K Davison, and
E O'Donnell, and
G Falkous, and
M Barron, and
J B Harris
June 1994,
Internal medicine (Tokyo, Japan),
L V Nicholson, and
M A Johnson, and
K Davison, and
E O'Donnell, and
G Falkous, and
M Barron, and
J B Harris
January 1994,
Acta neuropathologica,
L V Nicholson, and
M A Johnson, and
K Davison, and
E O'Donnell, and
G Falkous, and
M Barron, and
J B Harris
December 1987,
Cell,
L V Nicholson, and
M A Johnson, and
K Davison, and
E O'Donnell, and
G Falkous, and
M Barron, and
J B Harris
February 1994,
Muscle & nerve,
L V Nicholson, and
M A Johnson, and
K Davison, and
E O'Donnell, and
G Falkous, and
M Barron, and
J B Harris
October 1989,
Trends in biochemical sciences,
L V Nicholson, and
M A Johnson, and
K Davison, and
E O'Donnell, and
G Falkous, and
M Barron, and
J B Harris
June 1991,
Neurochemical research,
L V Nicholson, and
M A Johnson, and
K Davison, and
E O'Donnell, and
G Falkous, and
M Barron, and
J B Harris
August 1991,
Neuropediatrics,
L V Nicholson, and
M A Johnson, and
K Davison, and
E O'Donnell, and
G Falkous, and
M Barron, and
J B Harris
January 2006,
Journal of muscle research and cell motility,
