BIOMAT Database Logo BIOMAT Database Logo

Synthesis and biological evaluation of novel apio nucleosides with thiazole-4-carboxamide and 1,2,4-triazole-3-carboxamide. 2004

Myong Jung Kim, and Lak Shin Jeong, and Joong Hyup Kim, and Ji Hye Shin, and Soon Yong Chung, and Sang Kook Lee, and Moon Woo Chun
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea.

In view of biological activities of azole nucleosides and apio-dideoxynucleoside, novel apio nucleoside analogues (1 and 2) with thiazole and triazole base moiety were synthesized using 2,3-O-isopropylidene-apio-beta-D-furanose (3), which was prepared from D-mannose.

UI MeSH Term Description Entries
D008358 Mannose A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed) D-Mannose,Mannopyranose,Mannopyranoside,D Mannose
D009705 Nucleosides Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed) Nucleoside,Nucleoside Analog,Nucleoside Analogs,Analog, Nucleoside,Analogs, Nucleoside
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D013844 Thiazoles Heterocyclic compounds where the ring system is composed of three CARBON atoms, a SULFUR and NITROGEN atoms. Thiazole
D014230 Triazoles Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3. Triazole

Related Publications

Myong Jung Kim, and Lak Shin Jeong, and Joong Hyup Kim, and Ji Hye Shin, and Soon Yong Chung, and Sang Kook Lee, and Moon Woo Chun
1,2,4-Triazole amino nucleosides. 1-beta-D-3'-Amino-3'-deoxyribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides.
December 1977, Journal of medicinal chemistry,
Myong Jung Kim, and Lak Shin Jeong, and Joong Hyup Kim, and Ji Hye Shin, and Soon Yong Chung, and Sang Kook Lee, and Moon Woo Chun
Novel 4-phenoxypyridine derivatives bearing imidazole-4-carboxamide and 1,2,4-triazole-3-carboxamide moieties: Design, synthesis and biological evaluation as potent antitumor agents.
March 2022, Bioorganic chemistry,
Myong Jung Kim, and Lak Shin Jeong, and Joong Hyup Kim, and Ji Hye Shin, and Soon Yong Chung, and Sang Kook Lee, and Moon Woo Chun
5-alkylvinyl-1,2,4-triazole nucleosides: Synthesis and biological evaluation.
January 2020, Nucleosides, nucleotides & nucleic acids,
Myong Jung Kim, and Lak Shin Jeong, and Joong Hyup Kim, and Ji Hye Shin, and Soon Yong Chung, and Sang Kook Lee, and Moon Woo Chun
Design, synthesis and biological evaluation of novel 3-alkylsulfanyl-4-amino-1,2,4-triazole derivatives.
August 2016, Bioorganic & medicinal chemistry letters,
Myong Jung Kim, and Lak Shin Jeong, and Joong Hyup Kim, and Ji Hye Shin, and Soon Yong Chung, and Sang Kook Lee, and Moon Woo Chun
Synthesis of 1-(4-thio-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide.
June 1976, Journal of medicinal chemistry,
Myong Jung Kim, and Lak Shin Jeong, and Joong Hyup Kim, and Ji Hye Shin, and Soon Yong Chung, and Sang Kook Lee, and Moon Woo Chun
Nucleosides 5(15): synthesis of novel 1,2,4-triazolo[3,4-c]-1,2,4-triazole nucleosides.
November 2009, Nucleosides, nucleotides & nucleic acids,
Myong Jung Kim, and Lak Shin Jeong, and Joong Hyup Kim, and Ji Hye Shin, and Soon Yong Chung, and Sang Kook Lee, and Moon Woo Chun
1H-1,2,4-Triazole-3-carboxamide.
May 2008, Acta crystallographica. Section E, Structure reports online,
Myong Jung Kim, and Lak Shin Jeong, and Joong Hyup Kim, and Ji Hye Shin, and Soon Yong Chung, and Sang Kook Lee, and Moon Woo Chun
Spirohydantoins and 1,2,4-triazole-3-carboxamide derivatives as inhibitors of histone deacetylase: Design, synthesis, and biological evaluation.
February 2018, European journal of medicinal chemistry,
Myong Jung Kim, and Lak Shin Jeong, and Joong Hyup Kim, and Ji Hye Shin, and Soon Yong Chung, and Sang Kook Lee, and Moon Woo Chun
Synthesis and biological evaluation of novel tamoxifen-1,2,4-triazole conjugates.
August 2016, Molecular diversity,
Myong Jung Kim, and Lak Shin Jeong, and Joong Hyup Kim, and Ji Hye Shin, and Soon Yong Chung, and Sang Kook Lee, and Moon Woo Chun
Molecular docking studies, biological evaluation and synthesis of novel 3-mercapto-1,2,4-triazole derivatives.
February 2021, Molecular diversity,
Copied contents to your clipboard!