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[Changes on certain biochemical indexes for renal injury in workers exposed to lead]. 2004

Lin Tian, and Chunxiang Zhao, and Jianguo Li, and Xiaoting Lu
School of Public Health, Shanxi Medical University, Taiyuan 030001, China.

OBJECTIVE To explore changes of biochemical indexes for renal damage induced by lead. METHODS Contents of urinary total protein(TP), urinary beta 2-microglubin (beta 2-MG) and urinary-Acety-D-glucosamindase (NAG) activity of 103 workers in one storage battery plant were observed, then the relationships among work standing, urinary lead (Pb) content and three indexes were analyzed. RESULTS The levels of urinary TP(59.73 +/- 6.84) mg/gCr, urinary beta 2-MG (122.01 +/- 1.25) microgram/gCr and urinary NAG (13.70 +/- 1.62) U/g Crin exposed group were more higher than those in the control group and increased along with the rising level of urinary lead. The activities of urinary NAG in group of exposure years from 1 to 3 years were more higher than those in the control group. Increase in urinary NAG activity appeared earlier when compared with changes in urinary TP and beta 2-MG. CONCLUSIONS The change of NAG activity could reflect earlier the injury of the proximal tubular cells when compared with changes in urinary TP and beta 2-MG. The change of urinary NAG activity, together with change of urinary beta 2-MG or TP, could reflect the status of renal damage in lead-exposed workers.

UI MeSH Term Description Entries
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D007677 Kidney Function Tests Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine. Function Test, Kidney,Function Tests, Kidney,Kidney Function Test,Test, Kidney Function,Tests, Kidney Function
D007854 Lead A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000118 Acetylglucosaminidase A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue. N-Acetyl-beta-D-glucosaminidase,Chitobiase,N,N-Diacetylchitobiase,N-Ac-beta-Glucosaminidase,NAGase,beta-D-Acetamido-2-Deoxyglucosidase,beta-D-N-acetylglucosaminidase,beta-N-Acetylglucosaminidase,N Ac beta Glucosaminidase,N Acetyl beta D glucosaminidase,N,N Diacetylchitobiase,beta D Acetamido 2 Deoxyglucosidase,beta D N acetylglucosaminidase,beta N Acetylglucosaminidase
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001613 beta 2-Microglobulin An 11-kDa protein associated with the outer membrane of many cells including LYMPHOCYTES. It is the small subunit of MHC CLASS I MOLECULES. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, CEREBROSPINAL FLUID, and urine of healthy individuals, and to a much greater degree in the urine and plasma of patients with tubular PROTEINURIA, renal failure, or kidney transplants. Thymotaxin,beta 2 Microglobulin

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