BIOMAT Database Logo BIOMAT Database Logo

Impact of meal timing and frequency on the twenty-four-hour leptin rhythm. 2004

A J Fogteloo, and H Pijl, and F Roelfsema, and M Frölich, and A E Meinders
Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands. a.j.fogteloo@hotmail.com

OBJECTIVE To study the influence of changes in meal timing and frequency on the diurnal rhythm of leptin and on the 24-hour profile of insulin and glucose. METHODS Five obese women were studied twice during a weight-maintaining diet in either 3 daily or 8 day and night equal portions. Blood was sampled for 24-hour profiles of leptin and insulin. RESULTS During the 8-meal intervention, the 24-hour rhythm of leptin changed significantly: the amplitude decreased (p = 0.0089) and the acrophase was delayed by 168 min (p = 0.021). Also, 8 small insulin secretion peaks occurred instead of the 3 postprandial high insulin peaks. CONCLUSIONS The dispersion of food intake over 24 h affects the diurnal leptin rhythm. These changes could not be attributed to changes in circadian timing or energy balance. Instead, changes in daily insulin secretion profiles might play a role.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D009765 Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D002940 Circadian Rhythm The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli. Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D004734 Energy Metabolism The chemical reactions involved in the production and utilization of various forms of energy in cells. Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D005247 Feeding Behavior Behavioral responses or sequences associated with eating including modes of feeding, rhythmic patterns of eating, and time intervals. Dietary Habits,Eating Behavior,Faith-based Dietary Restrictions,Feeding Patterns,Feeding-Related Behavior,Food Habits,Diet Habits,Eating Habits,Behavior, Eating,Behavior, Feeding,Behavior, Feeding-Related,Behaviors, Eating,Behaviors, Feeding,Behaviors, Feeding-Related,Diet Habit,Dietary Habit,Dietary Restriction, Faith-based,Dietary Restrictions, Faith-based,Eating Behaviors,Eating Habit,Faith based Dietary Restrictions,Faith-based Dietary Restriction,Feeding Behaviors,Feeding Pattern,Feeding Related Behavior,Feeding-Related Behaviors,Food Habit,Habit, Diet,Habit, Dietary,Habit, Eating,Habit, Food,Habits, Diet,Pattern, Feeding,Patterns, Feeding,Restrictions, Faith-based Dietary
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D016000 Cluster Analysis A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both. Clustering,Analyses, Cluster,Analysis, Cluster,Cluster Analyses,Clusterings

Related Publications

A J Fogteloo, and H Pijl, and F Roelfsema, and M Frölich, and A E Meinders
Twenty-four-hour rhythm of prolactin depressive patients.
October 1979, Archives of general psychiatry,
A J Fogteloo, and H Pijl, and F Roelfsema, and M Frölich, and A E Meinders
Proceedings: Effects of microwaves on the twenty-four-hour rhythm and twenty-four-hour urinary excretion of seventeen hydroxycorticoids and seventeen ketosteroids.
June 1976, The Journal of microwave power,
A J Fogteloo, and H Pijl, and F Roelfsema, and M Frölich, and A E Meinders
[Twenty-four hour rhythm of clearance of urocathepsin and uropepsin].
January 1955, Acta medica Scandinavica. Supplementum,
A J Fogteloo, and H Pijl, and F Roelfsema, and M Frölich, and A E Meinders
Entrainment of the diurnal rhythm of plasma leptin to meal timing.
October 1997, The Journal of clinical investigation,
A J Fogteloo, and H Pijl, and F Roelfsema, and M Frölich, and A E Meinders
Twenty-four-hour variation in serum leptin in the elderly.
August 1999, Metabolism: clinical and experimental,
A J Fogteloo, and H Pijl, and F Roelfsema, and M Frölich, and A E Meinders
The twenty-four hour rhythm in urinary excretion of certain microelements.
February 1962, Biulleten' eksperimental'noi biologii i meditsiny,
A J Fogteloo, and H Pijl, and F Roelfsema, and M Frölich, and A E Meinders
Meal frequency and timing: impact on metabolic disease risk.
October 2016, Current opinion in endocrinology, diabetes, and obesity,
A J Fogteloo, and H Pijl, and F Roelfsema, and M Frölich, and A E Meinders
Twenty-four-hour blood pressure is not dependent on endogenous circadian rhythm.
April 1989, Journal of hypertension,
A J Fogteloo, and H Pijl, and F Roelfsema, and M Frölich, and A E Meinders
Continuous twenty-four hour recording of the fetal cardiac rhythm during normal pregnancies.
October 1984, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
A J Fogteloo, and H Pijl, and F Roelfsema, and M Frölich, and A E Meinders
Twenty-four hour rhythm of distal retinal pigment migration in the dwarf crawfish.
December 1957, Journal of cellular and comparative physiology,
Copied contents to your clipboard!