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A convenient method for regional monoamine oxidase-A determination by [14C]clorgyline autoradiography. 1992
M Murakami, and
Y Kondoh, and
Y Weimin, and
S Mizusawa, and
H Nakamichi, and
K Takahashi, and
H Sasaki, and
H Iida, and
S Miura, and
I Kanno
Department of Radiology, Research Institute for Brain and Blood Vessels-Akita, Japan.
The availability of clorgyline for regional monoamine oxidase-A (MAO-A) determination was examined using [14C]clorgyline in rat. [14C]Clorgyline was synthesized by the methylation reaction of N-desmethyl-clorgyline and [14C]methyliodide in dimethylformamide with high radiochemical yield. The MAO-A distribution map by autoradiography correlated with that by histochemical technique and its quantity was consistent with the calculated MAO-A amount based on previous reports. The combination of labeled clorgyline and autoradiographic technique will promise the quantitative measurement of regional MAO-A distribution.
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