BIOMAT Database Logo BIOMAT Database Logo

Isolation of Adda from microcystin-LR by microbial degradation. 2004

Ken-ichi Harada, and Susumu Imanishi, and Hajime Kato, and Masayoshi Mizuno, and Emiko Ito, and Kiyomi Tsuji
Graduate School of Environmental and Human Sciences, Meijo University, Tempaku, Nagoya 468-8503, Japan. kiharada@ccmfs.meijo-u.ac.jp

The intact Adda was isolated from microcystin-LR by a microbial degradation using an isolated Sphingomonas strain, B-9. The reaction of microcystin-LR with cell extract of this strain proceeded smoothly to give the final degradation product by way of two intermediates, linearized microcystin-LR and a tetrapeptide. The purified Adda that was structurally characterized using various spectral data did not show the toxicity to mice or inhibition to protein phosphatase activity in contrast to the native toxin.

UI MeSH Term Description Entries
D008387 Marine Toxins Toxic or poisonous substances elaborated by marine flora or fauna. They include also specific, characterized poisons or toxins for which there is no more specific heading, like those from poisonous FISHES. Marine Biotoxins,Phycotoxins
D009682 Magnetic Resonance Spectroscopy Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING). In Vivo NMR Spectroscopy,MR Spectroscopy,Magnetic Resonance,NMR Spectroscopy,NMR Spectroscopy, In Vivo,Nuclear Magnetic Resonance,Spectroscopy, Magnetic Resonance,Spectroscopy, NMR,Spectroscopy, Nuclear Magnetic Resonance,Magnetic Resonance Spectroscopies,Magnetic Resonance, Nuclear,NMR Spectroscopies,Resonance Spectroscopy, Magnetic,Resonance, Magnetic,Resonance, Nuclear Magnetic,Spectroscopies, NMR,Spectroscopy, MR
D010456 Peptides, Cyclic Peptides whose amino acid residues are linked together forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS; some are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL). Circular Peptide,Cyclic Peptide,Cyclic Peptides,Cyclopeptide,Orbitide,Circular Peptides,Cyclopeptides,Orbitides,Peptide, Circular,Peptide, Cyclic,Peptides, Circular
D000458 Cyanobacteria A phylum of oxygenic photosynthetic bacteria comprised of unicellular to multicellular bacteria possessing CHLOROPHYLL a and carrying out oxygenic PHOTOSYNTHESIS. Cyanobacteria are the only known organisms capable of fixing both CARBON DIOXIDE (in the presence of light) and NITROGEN. Cell morphology can include nitrogen-fixing heterocysts and/or resting cells called akinetes. Formerly called blue-green algae, cyanobacteria were traditionally treated as ALGAE. Algae, Blue-Green,Blue-Green Bacteria,Cyanophyceae,Algae, Blue Green,Bacteria, Blue Green,Bacteria, Blue-Green,Blue Green Algae,Blue Green Bacteria,Blue-Green Algae
D000596 Amino Acids Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins. Amino Acid,Acid, Amino,Acids, Amino
D001427 Bacterial Toxins Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases. Bacterial Toxin,Toxins, Bacterial,Toxin, Bacterial
D001673 Biodegradation, Environmental Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers. Bioremediation,Phytoremediation,Natural Attenuation, Pollution,Environmental Biodegradation,Pollution Natural Attenuation
D052998 Microcystins Cyclic heptapeptides found in MICROCYSTIS and other CYANOBACTERIA. Hepatotoxic and carcinogenic effects have been noted. They are sometimes called cyanotoxins, which should not be confused with chemicals containing a cyano group (CN) which are toxic. Cyanoginosins
D020578 Sphingomonas A genus of gram-negative, aerobic, rod-shaped bacteria characterized by an outer membrane that contains glycosphingolipids but lacks lipopolysaccharide. They have the ability to degrade a broad range of substituted aromatic compounds.

Related Publications

Ken-ichi Harada, and Susumu Imanishi, and Hajime Kato, and Masayoshi Mizuno, and Emiko Ito, and Kiyomi Tsuji
Microbial degradation of microcystin-LR by Ralstonia solanacearum.
December 2011, Environmental technology,
Ken-ichi Harada, and Susumu Imanishi, and Hajime Kato, and Masayoshi Mizuno, and Emiko Ito, and Kiyomi Tsuji
[Degradation of microcystin-lR by ozonation process].
November 2009, Huan jing ke xue= Huanjing kexue,
Ken-ichi Harada, and Susumu Imanishi, and Hajime Kato, and Masayoshi Mizuno, and Emiko Ito, and Kiyomi Tsuji
Electrochemical degradation of microcystin-LR.
January 2005, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering,
Ken-ichi Harada, and Susumu Imanishi, and Hajime Kato, and Masayoshi Mizuno, and Emiko Ito, and Kiyomi Tsuji
Microcystin LR degradation by Pseudomonas aeruginosa alkaline protease.
February 1997, Chemosphere,
Ken-ichi Harada, and Susumu Imanishi, and Hajime Kato, and Masayoshi Mizuno, and Emiko Ito, and Kiyomi Tsuji
Investigating the microbial dynamics of microcystin-LR degradation in Lake Erie sand.
June 2021, Chemosphere,
Ken-ichi Harada, and Susumu Imanishi, and Hajime Kato, and Masayoshi Mizuno, and Emiko Ito, and Kiyomi Tsuji
Unveiling new degradation intermediates/pathways from the photocatalytic degradation of microcystin-LR.
December 2008, Environmental science & technology,
Ken-ichi Harada, and Susumu Imanishi, and Hajime Kato, and Masayoshi Mizuno, and Emiko Ito, and Kiyomi Tsuji
Rapid detoxification of Microcystin-LR by selective catalytic hydrogenation of the Adda moiety using TiO2-supported Pd catalysts.
February 2022, Chemosphere,
Ken-ichi Harada, and Susumu Imanishi, and Hajime Kato, and Masayoshi Mizuno, and Emiko Ito, and Kiyomi Tsuji
Detoxification and degradation of microcystin-LR and -RR by ozonation.
April 2010, Chemosphere,
Ken-ichi Harada, and Susumu Imanishi, and Hajime Kato, and Masayoshi Mizuno, and Emiko Ito, and Kiyomi Tsuji
Photocatalytic degradation of microcystin-LR in aqueous solutions.
January 2013, Chemosphere,
Ken-ichi Harada, and Susumu Imanishi, and Hajime Kato, and Masayoshi Mizuno, and Emiko Ito, and Kiyomi Tsuji
Photocatalytic degradation of microcystin-LR by modified TiO2 photocatalysis: A review.
November 2020, The Science of the total environment,
Copied contents to your clipboard!