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The phenotypic and functional properties of T cells were evaluated in patients with tuberculin anergy and a possible role of anergic T cells in the development of immune deficiency in pulmonary tuberculosis (PT) was studied. The profound decrease (more than 50%) depressed T-cell proliferation in PPD-stimulated cultures was shown to be recorded in 44% (59/134) patients with PT. PPD hyporesponsiveness was associated with the low proliferation of anti-CD3 and SEB-stimulated proliferation of a healthy donor's mononuclear cells evidencing the enlargement of anergic T cells with a suppressive activity in PT. A PPD-stimulated response in healthy donors was under the negative control of CG25-positive cells. In the PPD-anergic patients, there was a significant increase in CD4+CD25+ T cells that were inversely correlated with the PPD-induced proliferative response. The development of tuberculin anergy was more pronounced in patients with drug resistance. The intensity of a PPD-stimulated response in patients with tuberculin anergy may be restored in the presence of exogenous interleukin-2.
L V Sakhno, and
M A Tikhonova, and
E V Kurganova, and
E Ia Shevela, and
S D Nikonov, and
O A Zhdanov, and
G V Mostovaia, and
A A Ostanin, and
E R Chernykh
January 1959,
Beitrage zur Klinik der Tuberkulose und spezifischen Tuberkulose-Forschung,
L V Sakhno, and
M A Tikhonova, and
E V Kurganova, and
E Ia Shevela, and
S D Nikonov, and
O A Zhdanov, and
G V Mostovaia, and
A A Ostanin, and
E R Chernykh
July 1946,
The Mississippi doctor,
L V Sakhno, and
M A Tikhonova, and
E V Kurganova, and
E Ia Shevela, and
S D Nikonov, and
O A Zhdanov, and
G V Mostovaia, and
A A Ostanin, and
E R Chernykh
January 1954,
Geneeskundige bladen uit kliniek en laboratorium voor de praktijk,
L V Sakhno, and
M A Tikhonova, and
E V Kurganova, and
E Ia Shevela, and
S D Nikonov, and
O A Zhdanov, and
G V Mostovaia, and
A A Ostanin, and
E R Chernykh
January 1959,
Excerpta medica. Section 15, Chest diseases,
L V Sakhno, and
M A Tikhonova, and
E V Kurganova, and
E Ia Shevela, and
S D Nikonov, and
O A Zhdanov, and
G V Mostovaia, and
A A Ostanin, and
E R Chernykh
June 1954,
Medizinische Monatsschrift,
L V Sakhno, and
M A Tikhonova, and
E V Kurganova, and
E Ia Shevela, and
S D Nikonov, and
O A Zhdanov, and
G V Mostovaia, and
A A Ostanin, and
E R Chernykh
March 1982,
The American review of respiratory disease,
L V Sakhno, and
M A Tikhonova, and
E V Kurganova, and
E Ia Shevela, and
S D Nikonov, and
O A Zhdanov, and
G V Mostovaia, and
A A Ostanin, and
E R Chernykh
June 1953,
Bulletin international des services de sante des armees de terre, de mer et de l'air,
L V Sakhno, and
M A Tikhonova, and
E V Kurganova, and
E Ia Shevela, and
S D Nikonov, and
O A Zhdanov, and
G V Mostovaia, and
A A Ostanin, and
E R Chernykh
January 1980,
Czechoslovak medicine,
L V Sakhno, and
M A Tikhonova, and
E V Kurganova, and
E Ia Shevela, and
S D Nikonov, and
O A Zhdanov, and
G V Mostovaia, and
A A Ostanin, and
E R Chernykh
January 1951,
Marseille medical,
L V Sakhno, and
M A Tikhonova, and
E V Kurganova, and
E Ia Shevela, and
S D Nikonov, and
O A Zhdanov, and
G V Mostovaia, and
A A Ostanin, and
E R Chernykh
July 2013,
The European respiratory journal,
