Biomaterial Database

Pseudouridine excretion in healthy subjects and its accumulation in renal failure. 1992

R Dzúrik, and I Lajdová, and V Spustová, and K Opatrný

Institute of Preventive and Clinical Medicine, Bratislava, Czechoslovakia.

Pseudouridine (psi) is a unique nucleoside accumulated in the sera of renal failure (RF) patients. Surprisingly data on its excretion are lacking. To get an overview, the psi serum level and urinary excretion were investigated in 73 healthy subjects (C), 16 patients not on dialysis (ND) and 12 hemodialysis patients (D). It was found: (a) psi accumulates in the sera of both ND and D patients. An inverse power correlation fits best with the relationship between serum psi and the clearance of endogenous creatinine (CCr). The amount of psi filtered in glomeruli of ND patients increases while it remains practically unchanged in D patients. However, the psi filtration load of residual nephrons increases with the decreasing CCr as a consequence of its increased serum concentration. (b) Both psi net resorption and secretion have been found in C subjects. The increased psi resorption diminishes the necessary increase of psi urinary excretion both in ND and D patients. The increase of psi resorption is marked if calculated on residual nephrons. (c) The slightly decreased psi excretion excludes the participation of its increased synthesis in its accumulation in RF. It is concluded that psi accumulation in RF is caused by the impairment of its kidney excretion and the increased psi resorption participates markedly in its retention.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D007676	Kidney Failure, Chronic	The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.	ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D011560	Pseudouridine	A naturally-occurring isomer of URIDINE found in RNA, in which ribosyl is attached to a carbon instead of a nitrogen atom.
D012016	Reference Values	The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.	Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D005919	Glomerular Filtration Rate	The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.	Filtration Rate, Glomerular,Filtration Rates, Glomerular,Glomerular Filtration Rates,Rate, Glomerular Filtration,Rates, Glomerular Filtration
D006435	Renal Dialysis	Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.	Dialysis, Extracorporeal,Dialysis, Renal,Extracorporeal Dialysis,Hemodialysis,Dialyses, Extracorporeal,Dialyses, Renal,Extracorporeal Dialyses,Hemodialyses,Renal Dialyses
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man