The master sex-determination locus in threespine sticklebacks is on a nascent Y chromosome. 2004

Catherine L Peichel, and Joseph A Ross, and Clinton K Matson, and Mark Dickson, and Jane Grimwood, and Jeremy Schmutz, and Richard M Myers, and Seiichi Mori, and Dolph Schluter, and David M Kingsley
Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, CA 94305, USA. cpeichel@fhcrc.org

BACKGROUND Many different environmental and genetic sex-determination mechanisms are found in nature. Closely related species can use different master sex-determination switches, suggesting that these developmental pathways can evolve very rapidly. Previous cytological studies suggest that recently diverged species of stickleback fish have different sex chromosome complements. Here, we investigate the genetic and chromosomal mechanisms that underlie sex determination in the threespine stickleback (Gasterosteus aculeatus). RESULTS Genome-wide linkage mapping identifies a single chromosome region at the distal end of linkage group (LG) 19, which controls male or female sexual development in threespine sticklebacks. Although sex chromosomes are not cytogenetically visible in this species, several lines of evidence suggest that LG 19 is an evolving sex chromosome system, similar to the XX female/XY male system in many other species: (1) males are consistently heterozygous for unique alleles in this region; (2) recombination between loci linked to the sex-determination region is reduced in male meiosis relative to female meiosis; (3) sequence analysis of X- and Y-specific bacterial artificial chromosome (BAC) clones from the sex-determination region reveals many sequence differences between the X- and Y-specific clones; and (4) the Y chromosome has accumulated transposable elements and local duplications. CONCLUSIONS Taken together, our data suggest that threespine sticklebacks have a simple chromosomal mechanism for sex determination based on a nascent Y chromosome that is less than 10 million years old. Further analysis of the stickleback system will provide an exciting window into the evolution of sex-determination pathways and sex chromosomes in vertebrates.

UI MeSH Term Description Entries
D008297 Male Males
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D010802 Phylogeny The relationships of groups of organisms as reflected by their genetic makeup. Community Phylogenetics,Molecular Phylogenetics,Phylogenetic Analyses,Phylogenetic Analysis,Phylogenetic Clustering,Phylogenetic Comparative Analysis,Phylogenetic Comparative Methods,Phylogenetic Distance,Phylogenetic Generalized Least Squares,Phylogenetic Groups,Phylogenetic Incongruence,Phylogenetic Inference,Phylogenetic Networks,Phylogenetic Reconstruction,Phylogenetic Relatedness,Phylogenetic Relationships,Phylogenetic Signal,Phylogenetic Structure,Phylogenetic Tree,Phylogenetic Trees,Phylogenomics,Analyse, Phylogenetic,Analysis, Phylogenetic,Analysis, Phylogenetic Comparative,Clustering, Phylogenetic,Community Phylogenetic,Comparative Analysis, Phylogenetic,Comparative Method, Phylogenetic,Distance, Phylogenetic,Group, Phylogenetic,Incongruence, Phylogenetic,Inference, Phylogenetic,Method, Phylogenetic Comparative,Molecular Phylogenetic,Network, Phylogenetic,Phylogenetic Analyse,Phylogenetic Clusterings,Phylogenetic Comparative Analyses,Phylogenetic Comparative Method,Phylogenetic Distances,Phylogenetic Group,Phylogenetic Incongruences,Phylogenetic Inferences,Phylogenetic Network,Phylogenetic Reconstructions,Phylogenetic Relatednesses,Phylogenetic Relationship,Phylogenetic Signals,Phylogenetic Structures,Phylogenetic, Community,Phylogenetic, Molecular,Phylogenies,Phylogenomic,Reconstruction, Phylogenetic,Relatedness, Phylogenetic,Relationship, Phylogenetic,Signal, Phylogenetic,Structure, Phylogenetic,Tree, Phylogenetic
D011995 Recombination, Genetic Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses. Genetic Recombination,Recombination,Genetic Recombinations,Recombinations,Recombinations, Genetic
D012091 Repetitive Sequences, Nucleic Acid Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES). DNA Repetitious Region,Direct Repeat,Genes, Selfish,Nucleic Acid Repetitive Sequences,Repetitive Region,Selfish DNA,Selfish Genes,DNA, Selfish,Repetitious Region, DNA,Repetitive Sequence,DNA Repetitious Regions,DNAs, Selfish,Direct Repeats,Gene, Selfish,Repeat, Direct,Repeats, Direct,Repetitious Regions, DNA,Repetitive Regions,Repetitive Sequences,Selfish DNAs,Selfish Gene
D002874 Chromosome Mapping Any method used for determining the location of and relative distances between genes on a chromosome. Gene Mapping,Linkage Mapping,Genome Mapping,Chromosome Mappings,Gene Mappings,Genome Mappings,Linkage Mappings,Mapping, Chromosome,Mapping, Gene,Mapping, Genome,Mapping, Linkage,Mappings, Chromosome,Mappings, Gene,Mappings, Genome,Mappings, Linkage
D003433 Crosses, Genetic Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species. Cross, Genetic,Genetic Cross,Genetic Crosses
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA

Related Publications

Catherine L Peichel, and Joseph A Ross, and Clinton K Matson, and Mark Dickson, and Jane Grimwood, and Jeremy Schmutz, and Richard M Myers, and Seiichi Mori, and Dolph Schluter, and David M Kingsley
July 2010, Molecular biology and evolution,
Catherine L Peichel, and Joseph A Ross, and Clinton K Matson, and Mark Dickson, and Jane Grimwood, and Jeremy Schmutz, and Richard M Myers, and Seiichi Mori, and Dolph Schluter, and David M Kingsley
January 1990, Reproduction, nutrition, development,
Catherine L Peichel, and Joseph A Ross, and Clinton K Matson, and Mark Dickson, and Jane Grimwood, and Jeremy Schmutz, and Richard M Myers, and Seiichi Mori, and Dolph Schluter, and David M Kingsley
April 1988, Lancet (London, England),
Catherine L Peichel, and Joseph A Ross, and Clinton K Matson, and Mark Dickson, and Jane Grimwood, and Jeremy Schmutz, and Richard M Myers, and Seiichi Mori, and Dolph Schluter, and David M Kingsley
December 1999, American journal of medical genetics,
Catherine L Peichel, and Joseph A Ross, and Clinton K Matson, and Mark Dickson, and Jane Grimwood, and Jeremy Schmutz, and Richard M Myers, and Seiichi Mori, and Dolph Schluter, and David M Kingsley
July 1988, Lancet (London, England),
Catherine L Peichel, and Joseph A Ross, and Clinton K Matson, and Mark Dickson, and Jane Grimwood, and Jeremy Schmutz, and Richard M Myers, and Seiichi Mori, and Dolph Schluter, and David M Kingsley
July 2007, Hippokratia,
Catherine L Peichel, and Joseph A Ross, and Clinton K Matson, and Mark Dickson, and Jane Grimwood, and Jeremy Schmutz, and Richard M Myers, and Seiichi Mori, and Dolph Schluter, and David M Kingsley
January 2022, Cell & bioscience,
Catherine L Peichel, and Joseph A Ross, and Clinton K Matson, and Mark Dickson, and Jane Grimwood, and Jeremy Schmutz, and Richard M Myers, and Seiichi Mori, and Dolph Schluter, and David M Kingsley
February 2009, Hypertension (Dallas, Tex. : 1979),
Catherine L Peichel, and Joseph A Ross, and Clinton K Matson, and Mark Dickson, and Jane Grimwood, and Jeremy Schmutz, and Richard M Myers, and Seiichi Mori, and Dolph Schluter, and David M Kingsley
January 1991, Annales d'endocrinologie,
Catherine L Peichel, and Joseph A Ross, and Clinton K Matson, and Mark Dickson, and Jane Grimwood, and Jeremy Schmutz, and Richard M Myers, and Seiichi Mori, and Dolph Schluter, and David M Kingsley
May 2007, Journal of evolutionary biology,
Copied contents to your clipboard!