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The influence of a monophasic sub-50 oral contraceptive (OC), Marvelon, on fasting total homocysteine levels was investigated in OC users and controls. Homocysteine levels in serum of OC users were significantly higher (P less than .01) than in controls during the low-hormonal phase of the cycles and comparable with levels determined in heterozygotes for homocystinuria. Blood levels of pyridoxal phosphate (PLP) were significantly lower (P less than .05) in OC users both in the low and high hormonal phase. However, there were no significant differences in the levels of homocysteine nor in folate and vitamin B12 between both groups in the high-hormonal phase. In contrast to the control group, the homocysteine levels in OC users in the high-hormonal phase of the cycle were significantly decreased compared with those on a low-hormonal day (P less than .05). These data suggest that cyclically recurrent periods of hyperhomocysteinemia do occur during sub-50 OC use in normal women and might be considered a predisposition to the occurrence of vascular complications.
R P Steegers-Theunissen, and
G H Boers, and
E A Steegers, and
F J Trijbels, and
C M Thomas, and
T K Eskes
January 1993,
Gynecologic and obstetric investigation,
R P Steegers-Theunissen, and
G H Boers, and
E A Steegers, and
F J Trijbels, and
C M Thomas, and
T K Eskes
September 2002,
Metabolism: clinical and experimental,
R P Steegers-Theunissen, and
G H Boers, and
E A Steegers, and
F J Trijbels, and
C M Thomas, and
T K Eskes
April 2006,
Contraception,
R P Steegers-Theunissen, and
G H Boers, and
E A Steegers, and
F J Trijbels, and
C M Thomas, and
T K Eskes
October 1970,
Diabetologia,
R P Steegers-Theunissen, and
G H Boers, and
E A Steegers, and
F J Trijbels, and
C M Thomas, and
T K Eskes
June 1986,
The Journal of reproductive medicine,
R P Steegers-Theunissen, and
G H Boers, and
E A Steegers, and
F J Trijbels, and
C M Thomas, and
T K Eskes
January 1976,
Advances in clinical chemistry,
R P Steegers-Theunissen, and
G H Boers, and
E A Steegers, and
F J Trijbels, and
C M Thomas, and
T K Eskes
October 1990,
American journal of obstetrics and gynecology,
R P Steegers-Theunissen, and
G H Boers, and
E A Steegers, and
F J Trijbels, and
C M Thomas, and
T K Eskes
September 1986,
The Journal of reproductive medicine,
R P Steegers-Theunissen, and
G H Boers, and
E A Steegers, and
F J Trijbels, and
C M Thomas, and
T K Eskes
October 1969,
Lancet (London, England),
R P Steegers-Theunissen, and
G H Boers, and
E A Steegers, and
F J Trijbels, and
C M Thomas, and
T K Eskes
October 1966,
Lancet (London, England),
