BIOMAT Database Logo BIOMAT Database Logo

Antibodies to thyroid peroxidase (TPOAb) in serum from patients with slightly raised thyrotropin (TSH) levels. 2004

Phillip Briston, and David Sinclair
Department of Chemical Pathology, Queen Alexandra Hospital, Portsmouth, UK. phil.briston@porthosp.nhs.uk

Assessment of thyroid antibody status can influence the decision to commence thyroxine replacement in patients with persistent marginally raised TSH concentrations. We studied 211 patients in whom we had reported a slightly raised TSH on two or more occasions. The most recent result was accompanied by a suggestion to repeat the TSH estimation and request thyroid antibodies. Although we received follow-up specimens on 59% of the audit sample, antibodies were requested on only 37%. However, a majority (62%) of those specimens showed a raised antibody concentration and this appeared to influence the decision to start thyroxine replacement. Our data suggest that it would be more effective if laboratory staff were to request thyroid antibodies on specimens from patients with persistently raised TSH concentrations and to comment further on the significance of the result.

UI MeSH Term Description Entries
D007037 Hypothyroidism A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction. Central Hypothyroidism,Primary Hypothyroidism,Secondary Hypothyroidism,TSH Deficiency,Thyroid-Stimulating Hormone Deficiency,Central Hypothyroidisms,Deficiency, TSH,Deficiency, Thyroid-Stimulating Hormone,Hormone Deficiency, Thyroid-Stimulating,Hypothyroidism, Central,Hypothyroidism, Primary,Hypothyroidism, Secondary,Hypothyroidisms,Primary Hypothyroidisms,Secondary Hypothyroidisms,TSH Deficiencies,Thyroid Stimulating Hormone Deficiency,Thyroid-Stimulating Hormone Deficiencies
D007453 Iodide Peroxidase A hemeprotein that catalyzes the oxidation of the iodide radical to iodine with the subsequent iodination of many organic compounds, particularly proteins. EC 1.11.1.8. Iodinase,Iodothyronine 5'-Deiodinase,Iodothyronine Deiodinase,Iodotyrosine Deiodase,Thyroid Peroxidase,Thyroxine 5'-Deiodinase,Thyroxine 5'-Monodeiodinase,5'-Deiodinase,Deiodinase,Iodotyrosine Deiodinase,Monodeiodinase,Reverse Triiodothyronine 5'-Deiodinase,T4-5'-Deiodinase,T4-Monodeiodinase,Tetraiodothyronine 5'-Deiodinase,Thyroxine Converting Enzyme,Triiodothyronine Deiodinase,5' Deiodinase,5'-Deiodinase, Iodothyronine,5'-Deiodinase, Reverse Triiodothyronine,5'-Deiodinase, Tetraiodothyronine,5'-Deiodinase, Thyroxine,5'-Monodeiodinase, Thyroxine,Deiodase, Iodotyrosine,Deiodinase, Iodothyronine,Deiodinase, Iodotyrosine,Deiodinase, Triiodothyronine,Enzyme, Thyroxine Converting,Iodothyronine 5' Deiodinase,Peroxidase, Iodide,Peroxidase, Thyroid,Reverse Triiodothyronine 5' Deiodinase,T4 5' Deiodinase,T4 Monodeiodinase,Tetraiodothyronine 5' Deiodinase,Thyroxine 5' Deiodinase,Thyroxine 5' Monodeiodinase,Triiodothyronine 5'-Deiodinase, Reverse
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000906 Antibodies Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
D013960 Thyroid Function Tests Blood tests used to evaluate the functioning of the thyroid gland. Jostel's TSH Index,Jostel's Thyrotropin Index,Protein-Bound Iodine Test,SPINA-GD,SPINA-GT,Secretory Capacity of the Thyroid Gland,Sum Activity of Peripheral Deiodinases,Thyrotroph Thyroid Hormone Sensitivity Index,Thyroid Gland Function Tests,Function Test, Thyroid,Iodine Test, Protein-Bound,Jostel TSH Index,Jostel Thyrotropin Index,Jostel's TSH Indices,Jostels TSH Index,Jostels Thyrotropin Index,Protein Bound Iodine Test,Protein-Bound Iodine Tests,TSH Index, Jostel's,Test, Protein-Bound Iodine,Test, Thyroid Function,Thyroid Function Test,Thyrotropin Index, Jostel's
D013972 Thyrotropin A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity. Thyroid-Stimulating Hormone,TSH (Thyroid Stimulating Hormone),Thyreotropin,Thyrotrophin,Hormone, Thyroid-Stimulating,Thyroid Stimulating Hormone
D019937 Diagnostic Techniques and Procedures Methods, procedures, and tests performed to diagnose disease, disordered function, or disability. Diagnostic Testing,Diagnostic Technics and Procedures,Technics and Procedures, Diagnostic,Techniques and Procedures, Diagnostic,Testing, Diagnostic

Related Publications

Phillip Briston, and David Sinclair
[Thyroid peroxidase antibodies (TPOAb)].
August 2005, Nihon rinsho. Japanese journal of clinical medicine,
Phillip Briston, and David Sinclair
[Antimicrosomal antibodies and thyroid peroxidase antibodies (TPOAb)].
July 2010, Nihon rinsho. Japanese journal of clinical medicine,
Phillip Briston, and David Sinclair
Transient hyperthyroxinemia in newborns from women with autoimmune thyroid disease and raised levels of thyroid peroxidase antibodies.
December 2006, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians,
Phillip Briston, and David Sinclair
Serum thyrotropin (TSH) levels after thyroid ablation compared with TSH levels after exogenous bovine TSH: implications for 131-I treatment of thyroid carcinoma.
May 1972, The Journal of clinical endocrinology and metabolism,
Phillip Briston, and David Sinclair
Serum thyrotropin (TSH) levels after recombinant human TSH injections in children and teenagers with papillary thyroid cancer.
December 2005, The Journal of clinical endocrinology and metabolism,
Phillip Briston, and David Sinclair
Establishment of reference distributions and decision values for thyroid antibodies against thyroid peroxidase (TPOAb), thyroglobulin (TgAb) and the thyrotropin receptor (TRAb).
January 2006, Clinical chemistry and laboratory medicine,
Phillip Briston, and David Sinclair
Falsely raised TSH levels due to human anti-mouse antibody interfering with thyrotropin assay.
November 2006, Postgraduate medical journal,
Phillip Briston, and David Sinclair
Relationships between metastases of differentiated thyroid carcinoma and serum thyrotropin (TSH) levels.
June 1977, The Journal of clinical endocrinology and metabolism,
Phillip Briston, and David Sinclair
Serum TSH levels and the thyroidal response to TSH stimulation in patients with thyroid disease.
January 1972, Annals of internal medicine,
Phillip Briston, and David Sinclair
Serum levels of antibodies to thyroid peroxidase correlate with quantitative descriptors of thyroid ultrasound images in patients with breast cancer.
January 2005, Prague medical report,
Copied contents to your clipboard!