BIOMAT Database Logo BIOMAT Database Logo

Predominant expansion of V gamma 9/V delta 2 T cells in a tularemia patient. 1992

T Sumida, and T Maeda, and H Takahashi, and S Yoshida, and F Yonaha, and A Sakamoto, and H Tomioka, and T Koike, and S Yoshida
Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.

We describe a 58-year-old man with tularemia and expanding gamma delta T cells in his peripheral blood lymphocytes (PBL) (32.7% of total PBL). In the present work, we analyzed the T-cell receptor V gamma/V delta repertoire of these cells by making use of the polymerase chain reaction and flow cytometry and found that they were mostly CD4- CD8- CD3+ V gamma 9/V delta 2+. The sequence analysis of 16 cDNA clones encoding the V gamma 9-J region revealed that the V gamma 9-Jp combination was strikingly overrepresented but that the junctional (N) region was heterogeneous. This suggested that the gamma delta T cells in PBL from a patient with tularemia were polyclonally expanded.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA
D013601 T-Lymphocytes Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen. T Cell,T Lymphocyte,T-Cells,Thymus-Dependent Lymphocytes,Cell, T,Cells, T,Lymphocyte, T,Lymphocyte, Thymus-Dependent,Lymphocytes, T,Lymphocytes, Thymus-Dependent,T Cells,T Lymphocytes,T-Cell,T-Lymphocyte,Thymus Dependent Lymphocytes,Thymus-Dependent Lymphocyte
D014406 Tularemia A plague-like disease of rodents, transmissible to man. It is caused by FRANCISELLA TULARENSIS and is characterized by fever, chills, headache, backache, and weakness. Francisella tularensis Infection,Francisella tularensis Infections,Infection, Francisella tularensis,Tularemias
D015704 CD4 Antigens 55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. They are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. T4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120. Antigens, CD4,CD4 Molecule,CD4 Receptor,CD4 Receptors,Receptors, CD4,T4 Antigens, T-Cell,CD4 Antigen,Receptors, Surface CD4,Surface CD4 Receptor,Antigen, CD4,Antigens, T-Cell T4,CD4 Receptor, Surface,CD4 Receptors, Surface,Receptor, CD4,Surface CD4 Receptors,T-Cell T4 Antigens,T4 Antigens, T Cell
D016133 Polymerase Chain Reaction In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships. Anchored PCR,Inverse PCR,Nested PCR,PCR,Anchored Polymerase Chain Reaction,Inverse Polymerase Chain Reaction,Nested Polymerase Chain Reaction,PCR, Anchored,PCR, Inverse,PCR, Nested,Polymerase Chain Reactions,Reaction, Polymerase Chain,Reactions, Polymerase Chain
D016692 Receptors, Antigen, T-Cell, gamma-delta T-cell receptors composed of CD3-associated gamma and delta polypeptide chains and expressed primarily in CD4-/CD8- T-cells. The receptors appear to be preferentially located in epithelial sites and probably play a role in the recognition of bacterial antigens. The T-cell receptor gamma/delta chains are separate and not related to the gamma and delta chains which are subunits of CD3 (see ANTIGENS, CD3). Antigen Receptors, T-Cell, gamma-delta,T-Cell Receptors delta-Chain,T-Cell Receptors gamma-Chain,T-Cell Receptors, gamma-delta,TcR gamma-delta,Antigen T Cell Receptor, delta Chain,Antigen T Cell Receptor, gamma Chain,Receptors, Antigen, T Cell, gamma delta,T Cell Receptors, gamma delta,T-Cell Receptor delta-Chain,T-Cell Receptor gamma-Chain,T-Cell Receptor, gamma-delta,T Cell Receptor delta Chain,T Cell Receptor gamma Chain,T Cell Receptor, gamma delta,T Cell Receptors delta Chain,T Cell Receptors gamma Chain,TcR gamma delta,delta-Chain, T-Cell Receptor,delta-Chain, T-Cell Receptors,gamma-Chain, T-Cell Receptor,gamma-Chain, T-Cell Receptors,gamma-delta T-Cell Receptor,gamma-delta T-Cell Receptors,gamma-delta, TcR

Related Publications

T Sumida, and T Maeda, and H Takahashi, and S Yoshida, and F Yonaha, and A Sakamoto, and H Tomioka, and T Koike, and S Yoshida
Peripheral expansion of human V gamma 9/V delta 2 T cells.
December 1994, Journal of immunology (Baltimore, Md. : 1950),
T Sumida, and T Maeda, and H Takahashi, and S Yoshida, and F Yonaha, and A Sakamoto, and H Tomioka, and T Koike, and S Yoshida
Predominant activation and expansion of V gamma 9-bearing gamma delta T cells in vivo as well as in vitro in Salmonella infection.
July 1992, The Journal of clinical investigation,
T Sumida, and T Maeda, and H Takahashi, and S Yoshida, and F Yonaha, and A Sakamoto, and H Tomioka, and T Koike, and S Yoshida
Selective outgrowth of CD45RO+ V gamma 9+/V delta 2+ T-cell receptor gamma/delta T cells early after bone marrow transplantation.
October 1991, Blood,
T Sumida, and T Maeda, and H Takahashi, and S Yoshida, and F Yonaha, and A Sakamoto, and H Tomioka, and T Koike, and S Yoshida
Human V gamma 9-V delta 2 T cell receptor-gamma delta lymphocytes show specificity to Daudi Burkitt's lymphoma cells.
November 1990, Journal of immunology (Baltimore, Md. : 1950),
T Sumida, and T Maeda, and H Takahashi, and S Yoshida, and F Yonaha, and A Sakamoto, and H Tomioka, and T Koike, and S Yoshida
Preferential expansion of V gamma 9 V delta 2 T cells following stimulation of peripheral blood lymphocytes with extracts of Plasmodium falciparum.
March 1992, International immunology,
T Sumida, and T Maeda, and H Takahashi, and S Yoshida, and F Yonaha, and A Sakamoto, and H Tomioka, and T Koike, and S Yoshida
An in vitro model for the expansion of V gamma 9 delta 2 T lymphocytes during development.
November 1994, Scandinavian journal of immunology,
T Sumida, and T Maeda, and H Takahashi, and S Yoshida, and F Yonaha, and A Sakamoto, and H Tomioka, and T Koike, and S Yoshida
Expansion of selected V delta 1+ gamma delta T cells in systemic sclerosis patients.
July 1994, Journal of immunology (Baltimore, Md. : 1950),
T Sumida, and T Maeda, and H Takahashi, and S Yoshida, and F Yonaha, and A Sakamoto, and H Tomioka, and T Koike, and S Yoshida
Oligoclonal expansion of V delta 1+ gamma/delta T-cells in systemic sclerosis patients.
July 1995, Annals of the New York Academy of Sciences,
T Sumida, and T Maeda, and H Takahashi, and S Yoshida, and F Yonaha, and A Sakamoto, and H Tomioka, and T Koike, and S Yoshida
Function and specificity of human V gamma 9/V delta 2 T lymphocytes.
January 1991, Current topics in microbiology and immunology,
T Sumida, and T Maeda, and H Takahashi, and S Yoshida, and F Yonaha, and A Sakamoto, and H Tomioka, and T Koike, and S Yoshida
Large scale expansion of gamma 9 delta 2 T lymphocytes: Innacell gamma delta cell therapy product.
September 2007, Journal of immunological methods,
Copied contents to your clipboard!