-transparent.png){kind=logo}
6beta-Azido-7alpha-hydroxy-17-oxo-5alpha-androstan-3beta-yl acetate. 2004
J I F Paixão, and
J A R Salvador, and
J A Paixão, and
A Matos Beja, and
M Ramos Silva, and
A M d'A Rocha Gonsalves
Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, P-3004-535 Coimbra, Portugal.
In the title compound, C21H31N3O4, a potential inhibitor of aromatase, all rings are fused trans. Rings A, B and C have chair conformations which are slightly flattened. Ring D has a 14alpha-envelope conformation. The steroid nucleus has a small twist, as shown by the C19-C10...C13-C18 torsion angle of 6.6 (2) degrees. Ab initio calculations of the equilibrium geometry of the molecule reproduce this small twist, which appears to be due to the steric effect of the 6beta-azide substituent rather than to packing effects.
Related Publications
J I F Paixão, and
J A R Salvador, and
J A Paixão, and
A Matos Beja, and
M Ramos Silva, and
A M d'A Rocha Gonsalves
January 1976,
Journal of the Chemical Society. Perkin transactions 1,
J I F Paixão, and
J A R Salvador, and
J A Paixão, and
A Matos Beja, and
M Ramos Silva, and
A M d'A Rocha Gonsalves
September 2008,
Acta crystallographica. Section C, Crystal structure communications,
J I F Paixão, and
J A R Salvador, and
J A Paixão, and
A Matos Beja, and
M Ramos Silva, and
A M d'A Rocha Gonsalves
January 1977,
Biochimie,
J I F Paixão, and
J A R Salvador, and
J A Paixão, and
A Matos Beja, and
M Ramos Silva, and
A M d'A Rocha Gonsalves
December 2001,
Bioorganic & medicinal chemistry,
J I F Paixão, and
J A R Salvador, and
J A Paixão, and
A Matos Beja, and
M Ramos Silva, and
A M d'A Rocha Gonsalves
February 1975,
Endocrinology,
J I F Paixão, and
J A R Salvador, and
J A Paixão, and
A Matos Beja, and
M Ramos Silva, and
A M d'A Rocha Gonsalves
February 2009,
Steroids,
J I F Paixão, and
J A R Salvador, and
J A Paixão, and
A Matos Beja, and
M Ramos Silva, and
A M d'A Rocha Gonsalves
February 1998,
Biulleten' eksperimental'noi biologii i meditsiny,
J I F Paixão, and
J A R Salvador, and
J A Paixão, and
A Matos Beja, and
M Ramos Silva, and
A M d'A Rocha Gonsalves
June 1976,
European journal of biochemistry,
J I F Paixão, and
J A R Salvador, and
J A Paixão, and
A Matos Beja, and
M Ramos Silva, and
A M d'A Rocha Gonsalves
December 2004,
Life sciences,
J I F Paixão, and
J A R Salvador, and
J A Paixão, and
A Matos Beja, and
M Ramos Silva, and
A M d'A Rocha Gonsalves
September 1979,
Steroids,
