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Changes in basal and stimulated acid secretion after duodenal ulcer healing have been previously shown to be influenced by the nature of the treatment. This study aimed to determine possible changes in nocturnal acid secretion on duodenal ulcer healing in patients treated with sucralfate or ranitidine. Nocturnal acid output and peak acid output in response to pentagastrin stimulation were studied in 20 patients before and after duodenal ulcer healing with sucralfate (n = 9) or ranitidine (n = 11). Details regarding cigarette smoking were obtained from each subject. Median 10 hour nocturnal acid output fell significantly (p less than 0.05) from 82.4 (29.1-188.3) mmol (median range) to 45.2 (14.7-144.4) mmol after healing with sucralfate, and rose significantly (p less than 0.05) from 54.7 (16.8-74.3) mmol to 86.2 (11.7-118.1) mmol after ulcer healing with ranitidine. Peak acid output fell from 39.6 (22.0-52.8) mmol/hour to 27.8 (13.8-38.2) mmol/hour (p less than 0.01) after healing with sucralfate and was unchanged after healing with ranitidine. There was no correlation between smoking and nocturnal acid output. These results provide further evidence that acid secretion decreases with sucralfate healing and remains the same or may even increase after ranitidine healing.
A F Kummer, and
D A Johnston, and
I N Marks, and
G O Young, and
N A Tigler-Wybrandi, and
S A Bridger
August 1991,
The American journal of medicine,
A F Kummer, and
D A Johnston, and
I N Marks, and
G O Young, and
N A Tigler-Wybrandi, and
S A Bridger
August 1988,
Journal of clinical gastroenterology,
A F Kummer, and
D A Johnston, and
I N Marks, and
G O Young, and
N A Tigler-Wybrandi, and
S A Bridger
June 1989,
The American journal of medicine,
A F Kummer, and
D A Johnston, and
I N Marks, and
G O Young, and
N A Tigler-Wybrandi, and
S A Bridger
January 1998,
The Journal of international medical research,
A F Kummer, and
D A Johnston, and
I N Marks, and
G O Young, and
N A Tigler-Wybrandi, and
S A Bridger
June 1989,
The American journal of medicine,
A F Kummer, and
D A Johnston, and
I N Marks, and
G O Young, and
N A Tigler-Wybrandi, and
S A Bridger
January 1986,
Klinische Wochenschrift,
A F Kummer, and
D A Johnston, and
I N Marks, and
G O Young, and
N A Tigler-Wybrandi, and
S A Bridger
June 1986,
British medical journal (Clinical research ed.),
A F Kummer, and
D A Johnston, and
I N Marks, and
G O Young, and
N A Tigler-Wybrandi, and
S A Bridger
July 1988,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
A F Kummer, and
D A Johnston, and
I N Marks, and
G O Young, and
N A Tigler-Wybrandi, and
S A Bridger
April 1988,
The Journal of the Association of Physicians of India,
A F Kummer, and
D A Johnston, and
I N Marks, and
G O Young, and
N A Tigler-Wybrandi, and
S A Bridger
August 1991,
The American journal of medicine,
