-transparent.png){kind=logo}
Bordetella pertussis 165-9K/129G, which produces a nontoxic form of pertussis toxin (PT), was used to prepare a whole-cell diphtheria-tetanus-pertussis (DTP) vaccine. The in vivo potency and the serological response induced by this vaccine were comparable to those of the conventional DTP vaccine which contains active PT. The toxic activities induced by PT such as leukocytosis, histamine sensitivity, and potentiation of anaphylactic reactions, which are present in the conventional DTP vaccine, were absent in the new vaccine. These results suggest that the introduction of a whole-cell vaccine containing B. pertussis 165-9K/129G would induce the same immunity as the conventional vaccine and would avoid the administration of a harmful toxin to children.
I Marsili, and
M Pizza, and
F Giovannoni, and
G Volpini, and
M Bartalini, and
R Olivieri, and
R Rappuoli, and
L Nencioni
February 2016,
Emerging infectious diseases,
I Marsili, and
M Pizza, and
F Giovannoni, and
G Volpini, and
M Bartalini, and
R Olivieri, and
R Rappuoli, and
L Nencioni
January 2020,
Journal of medical microbiology,
I Marsili, and
M Pizza, and
F Giovannoni, and
G Volpini, and
M Bartalini, and
R Olivieri, and
R Rappuoli, and
L Nencioni
August 2011,
Journal of bacteriology,
I Marsili, and
M Pizza, and
F Giovannoni, and
G Volpini, and
M Bartalini, and
R Olivieri, and
R Rappuoli, and
L Nencioni
January 1992,
Applied and environmental microbiology,
I Marsili, and
M Pizza, and
F Giovannoni, and
G Volpini, and
M Bartalini, and
R Olivieri, and
R Rappuoli, and
L Nencioni
February 2015,
Genome announcements,
I Marsili, and
M Pizza, and
F Giovannoni, and
G Volpini, and
M Bartalini, and
R Olivieri, and
R Rappuoli, and
L Nencioni
January 2010,
Molekuliarnaia genetika, mikrobiologiia i virusologiia,
I Marsili, and
M Pizza, and
F Giovannoni, and
G Volpini, and
M Bartalini, and
R Olivieri, and
R Rappuoli, and
L Nencioni
January 2023,
Frontiers in immunology,
I Marsili, and
M Pizza, and
F Giovannoni, and
G Volpini, and
M Bartalini, and
R Olivieri, and
R Rappuoli, and
L Nencioni
April 2019,
Microbiology resource announcements,
I Marsili, and
M Pizza, and
F Giovannoni, and
G Volpini, and
M Bartalini, and
R Olivieri, and
R Rappuoli, and
L Nencioni
October 1963,
Journal of bacteriology,
I Marsili, and
M Pizza, and
F Giovannoni, and
G Volpini, and
M Bartalini, and
R Olivieri, and
R Rappuoli, and
L Nencioni
September 1991,
Vaccine,
