Biomaterial Database

Toxicology of organic phosphate insecticides. 1950

H K ABRAMS, and A R LEONARD

The development of effective new insecticides has created potential industrial health hazards to people engaged in their manufacture and application, as well as to those with casual exposures. A group of these insecticides known as the organic phosphates is extremely toxic, destroying the enzyme cholinesterase and exerting a cholinergic action on the mammalian animal. A discussion of the origin, chemistry, and pharmacology of these compounds, along with a description of symptoms, diagnosis and treatment of poisoning is presented. Methods of prevention of poisoning and control measures for the safe use of these compounds are described.

UI	MeSH Term	Description	Entries
D007306	Insecticides	Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.	Insecticide
D009943	Organophosphorus Compounds	Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.	Organophosphorus Compound,Organopyrophosphorus Compound,Organopyrophosphorus Compounds,Compound, Organophosphorus,Compound, Organopyrophosphorus,Compounds, Organophosphorus,Compounds, Organopyrophosphorus
D010755	Organophosphates	Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or more OXYGEN atoms of the P(	Organophosphate,Phosphates, Organic,Phosphoric Acid Esters,Organopyrophosphates,Acid Esters, Phosphoric,Esters, Phosphoric Acid,Organic Phosphates
D010758	Phosphorus	A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.	Black Phosphorus,Phosphorus-31,Red Phosphorus,White Phosphorus,Yellow Phosphorus,Phosphorus 31,Phosphorus, Black,Phosphorus, Red,Phosphorus, White,Phosphorus, Yellow
D002802	Cholinesterases		Acylcholineacylhydrolase,Cholase,Cholinesterase
D016226	Phosphorus, Dietary	Phosphorus used in foods or obtained from food. This element is a major intracellular component which plays an important role in many biochemical pathways relating to normal physiological functions. High concentrations of dietary phosphorus can cause nephrocalcinosis which is associated with impaired kidney function. Low concentrations of dietary phosphorus cause an increase in calcitriol in the blood and osteoporosis.	Dietary Phosphorus
D016272	Occupational Health	The promotion and maintenance of physical and mental health in the work environment.	Employee Health,Industrial Health,Industrial Hygiene,Occupational Safety,Health, Industrial,Hygiene, Industrial,Safety, Occupational,Health, Employee,Health, Occupational
D017553	Phosphorus Compounds	Inorganic compounds that contain phosphorus as an integral part of the molecule.	Compounds, Phosphorus