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The present paper was designed to the study of cerebral edema induced by intracarotid infusion of dinitrophenol. The determinations included variations in three lysosomal enzymes (acid phosphatase, cathepsin C and beta-glucuronidase), Na+-K+-ATP-ase, changes in cerebral RNA and protein concentrations and the synthesis of these macromolecules in vitro. In experimental brain edema a drastic drop in the activity of lysosomal enzymes took place. The acid phosphatase decreased to less than 30% of controls. Cathepsin C and beta-glucuronidase were reduced about 30% and 50% of control levels respectively. Protein concentration in the cerebral tissue also decreased by more than 50%. The concentration of RNA, RNA synthesis, and the level of Na+-K+-ATP-ase remained unchanged. Protein synthesis was stimulated by 75% (against controls). All these phenomena were suppressed when the animals subjected to the action of dinitrophenol were concomitantly treated with the antiacidotic substance, tris (hydroxymethyl) aminomethane.
C T Dragomir, and
D Alexianu, and
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A Barbier, and
I Dinu, and
C Eşanu, and
D T Stefánescu, and
S Mihåileanu
November 1981,
Experimental eye research,
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D Alexianu, and
D Ungureanu, and
A Barbier, and
I Dinu, and
C Eşanu, and
D T Stefánescu, and
S Mihåileanu
December 1975,
Journal of neurochemistry,
C T Dragomir, and
D Alexianu, and
D Ungureanu, and
A Barbier, and
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S Mihåileanu
May 1987,
Neurologia medico-chirurgica,
C T Dragomir, and
D Alexianu, and
D Ungureanu, and
A Barbier, and
I Dinu, and
C Eşanu, and
D T Stefánescu, and
S Mihåileanu
February 1967,
Klinische Wochenschrift,
C T Dragomir, and
D Alexianu, and
D Ungureanu, and
A Barbier, and
I Dinu, and
C Eşanu, and
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January 1991,
Roczniki Panstwowego Zakladu Higieny,
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S Mihåileanu
May 1977,
Biochemical pharmacology,
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D Alexianu, and
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A Barbier, and
I Dinu, and
C Eşanu, and
D T Stefánescu, and
S Mihåileanu
March 1969,
No to shinkei = Brain and nerve,
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D Alexianu, and
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A Barbier, and
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C Eşanu, and
D T Stefánescu, and
S Mihåileanu
January 2014,
BioMed research international,
C T Dragomir, and
D Alexianu, and
D Ungureanu, and
A Barbier, and
I Dinu, and
C Eşanu, and
D T Stefánescu, and
S Mihåileanu
April 1983,
Neurochemical research,
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C Eşanu, and
D T Stefánescu, and
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January 1982,
Experimental brain research,
