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Superoxide production from human polymorphonuclear leukocytes by human mannan-binding protein (MBP). 2004
Kazuhide Uemura, and
Harumi Yamamoto, and
Tomoaki Nakagawa, and
Kishiko Nakamura, and
Nobuko Kawasaki, and
Shogo Oka, and
Bruce Yong Ma, and
Toshisuke Kawasaki
Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501 Japan.
Mannan-binding protein (MBP) is a Ca(2+)-dependent mammalian lectin that plays an important role in innate immunity. In this study, we found that ligand-bound MBP stimulates polymorphonuclear leukocytes (PMN) to induce cell aggregation and superoxide production. The biological response of PMN to ligand-bound MBP was dose- and time-dependent. The PMN aggregation and superoxide production induced by ligand-bound MBP was blocked completely by pertussis toxin, and partially blocked by a platelet activation factor receptor antagonist, TCV-309. These findings suggest that the ligand-bound MBP stimulates PMN through a putative MBP receptor(s) on PMN.
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