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Gianotti-Crosti syndrome caused by acute hepatitis B virus genotype D infection. 2004
Kojiro Michitaka, and
Norio Horiike, and
Yan Chen, and
Tran Nhu Duong, and
Ichiro Konishi, and
Toshie Mashiba, and
Yoshio Tokumoto, and
Yoichi Hiasa, and
Yasuhito Tanaka, and
Masashi Mizokami, and
Morikazu Onji
Endoscopy Center, Ehime University School of Medicine, Shigenobucho, Onsen-gun, Ehime 791-0295.
A 12-year-old girl with Gianotti-Crosti syndrome caused by hepatitis B virus (HBV) infection was admitted due to eruption on her extremities. Laboratory findings revealed elevation of transaminase, positivity for HB surface antigen (HBsAg), and an IgM type anti-HB core. The eruption and level of transaminase improved, and HBsAg became negative within 2 months of onset. Analysis of the virus revealed it to be genotype D with a genomic length of 3,182 bases and the HBsAg serotype was ayw3, which is very rare in Japan. The possible relationship between Gianotti-Crosti syndrome and HBV genotype D infection is discussed.
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