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To study the secretory immune response after Shigella infection, the anti-lipopolysaccharide and anti-Shiga-toxin response in saliva, obtained from children with confirmed shigellosis and healthy children, were determined by enzyme-linked immunosorbent assay and by Western blot. Children with infection showed high titers compared to healthy controls. After Shigella dysenteriae type 1 infection a significant change in titer could be observed in a large number of cases, in contrast to Shigella flexneri infection. It appeared that, in children living in endemic areas, infection with one serotype can give a rise in antibody titer to another serotype. This could be ascribed to polyclonal B cell activation since children in endemic areas routinely show relatively high titers to Shigella antigens. We conclude that the dynamics of salivary anti-Shigella LPS and anti-Shiga-toxin in children with dysentery indicate that it can be applied to studies of immune response in shigellosis for epidemiological and vaccination purposes.
C Schultsz, and
F Qadri, and
S A Hossain, and
F Ahmed, and
I Ciznar
March 1952,
A.M.A. archives of internal medicine,
C Schultsz, and
F Qadri, and
S A Hossain, and
F Ahmed, and
I Ciznar
May 1950,
The American journal of nursing,
C Schultsz, and
F Qadri, and
S A Hossain, and
F Ahmed, and
I Ciznar
December 1951,
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C Schultsz, and
F Qadri, and
S A Hossain, and
F Ahmed, and
I Ciznar
June 1948,
American journal of clinical pathology,
C Schultsz, and
F Qadri, and
S A Hossain, and
F Ahmed, and
I Ciznar
December 1969,
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C Schultsz, and
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I Ciznar
June 1991,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
C Schultsz, and
F Qadri, and
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I Ciznar
February 1953,
Pediatrics,
C Schultsz, and
F Qadri, and
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I Ciznar
November 1989,
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C Schultsz, and
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S A Hossain, and
F Ahmed, and
I Ciznar
July 1977,
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C Schultsz, and
F Qadri, and
S A Hossain, and
F Ahmed, and
I Ciznar
June 1962,
Voprosy okhrany materinstva i detstva,
