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In vitro antiviral diterpenes from the Brazilian brown alga Dictyota pfaffii. 2004
Jussara Pinheiro Barbosa, and
Renato Crespo Pereira, and
Juliana Lourenço Abrantes, and
Cláudio César Cirne dos Santos, and
Moacyr Alcoforado Rebello, and
Izabel Christina de Palmer Paixão Frugulhetti, and
Valéria Laneuville Texeira
Post-Graduate Program in Organic Chemistry, Institute of Chemistry, Universidade Federal Fluminense, Niterói, 24001-970 Rio de Janeiro, Brazil.
Specimens of Dictyota pfaffii from Atol das Rocas, Northeast Brazil, afforded the rare dolabellane diterpene 10,18-diacetoxy-8-hydroxy-2, 6-dolabelladiene (1) and the new 10-acetoxy-8,18-di-hydroxy-2,6-dolabelladiene (2). Reduction of 1 yielded 8,10,18-trihydroxy-2,6-dolabelladiene (3), also present in the crude ex-tract of D. pfaffii. All three structures were assigned by 1D and 2D NMR spectral data. These substances showed strong anti-HSV-1 activity in vitro but only 3 inhibited the reverse transcriptase enzyme of HIV-1.
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