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Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. 2004
Karine G Le Roch, and
Jeffrey R Johnson, and
Laurence Florens, and
Yingyao Zhou, and
Andrey Santrosyan, and
Munira Grainger, and
S Frank Yan, and
Kim C Williamson, and
Anthony A Holder, and
Daniel J Carucci, and
John R Yates, and
Elizabeth A Winzeler
Department of Cell Biology ICND202, the Scripps Research Institute, La Jolla, California 92037, USA.
To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein abundance levels for seven different stages of the parasite life cycle. A moderately high positive relationship between mRNA and protein abundance was observed for these stages; the most common discrepancy was a delay between mRNA and protein accumulation. Potentially post-transcriptionally regulated genes are identified, and families of functionally related genes were observed to share similar patterns of mRNA and protein accumulation.
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